Degradomer D-1 | IRAK3 PROTAC | Probechem Biochemicals

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Chemical Structure : Degradomer D-1

Degradomer D-1 (IRAK3 PROTAC)

Catalog No.: PC-38738Not For Human Use, Lab Use Only.

Degradomer D-1 is a selective proteasomal degrader of IRAK3 with Kd of 100 nM, DC50 of 94 nM, displays no binding affinity against IRAK4 (Ki >10 uM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Degradomer D-1 is a selective proteasomal degrader of IRAK3 with Kd of 100 nM, DC50 of 94 nM, displays no binding affinity against IRAK4 (Ki >10 uM).

Physicochemical Properties

M.Wt	1031.083
Formula	C52H62Cl2FN9O6S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S,4R)-1-((S)-2-((1r,4S)-4-(4-(4-(6-amino-5-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-1H-pyrazol-1-yl)piperidine-1-carbonyl)cyclohexane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide

References

1. Ann Rowley, et al. ACS Chem Biol. May 17, 2022.

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