| Cat. No. |
Product Name |
Information |
| PC-22391 |
WEE1 degrader 2
WEE1 degrader
|
WEE1 degrader 2 is a potent, selective CRBN-dependent WEE1 molecular glue degrader with DC50 of 140 nM and Emax of 85%, does not degrade CK1α. |
| PC-22390 |
WEE1 degrader 1
WEE1 degrader
|
WEE1 degrader 1 is a potent, selective CRBN-dependent WEE1 molecular glue degrader with DC50 of 91 nM, does not degrade CK1α. |
| PC-22339 |
LLC355
DDR1 degrader
|
LLC355 is a potent DDR1 degrader and autophagosome-tethering compound (ATTEC) with DC50 of 150.8 nM in NCI-H23 cells, induce DDR1 degradation via lysosome-mediated autophagy, potently suppresses cancer cell tumorigenicity, migration, and invasion. |
| PC-22314 |
LC-MI-3
IRAK4 degrader
|
LC-MI-3 is a potent, selective and orally bioavailable PROTAC degrader of interleukin-1 receptor-associated kinase 4 (IRAK4) with DC50 of 47.3 nM in RAW264.7 cells, Dmax of 91%. |
| PC-22303 |
JYQ-194
PARK7 degrader
|
JYQ-194 (JYQ194) is a first-in-class, selective PARK7 PROTAC degrader, induces degradation of PARK7 starting at 0.1 uM and reaching a Dmax of 80% at a concentration of 5 uM in A549 cells. |
| PC-22253 |
AKR1C3 PROTAC 5
AKR1C3 degrader
|
AKR1C3 PROTAC 5 is a first-in-class Aldo-Keto reductase 1C3 (AKR1C3) PROTAC degrader with DC50 of 52 nM in 22Rv1 cells, AKR1C1/C2 DC50 of 49 nM, ARv7 DC50 of 70 nM. |
| PC-22219 |
EBET-1593
BET degrader
|
EBET-593 is a bromodomain and extra-terminal (BET) protein degrader, effectively kills PDAC cells, and modulates cancer-associated fibroblasts (CAFs) in PDAC. |
| PC-22215 |
EBET-1055
BET degrader
|
EBET-1055 is a bromodomain and extra-terminal (BET) protein degrader, effectively kills PDAC cells, and modulates cancer-associated fibroblasts (CAFs) in PDAC. |
| PC-22214 |
BR-cpd7
FGFR1/2 degrader
|
BR-cpd7 is a potent, selective FGFR1/2-targeting proteolysis targeting chimeric (PROTAC) degrader with DC50 of 10 nM, while sparing FGFR3. |
| PC-22126 |
LD4172
RIPK1 degrader
|
LD4172 is a first-in-class RIPK1 PROTAC degrader with DC50 values of 4-400 nM in a panel of human and mouse cancer cell lines. |
| PC-22099 |
MS170
AKT PROTAC degrader
|
MS170 (AKT PROTAC degrader) is a potent, selective, cereblon (CRBN)-recruiting AKT PROTAC degrader with DC50 of 32 nM (cellular T-AKT in BT474 cells). |
| PC-22098 |
MS98
AKT PROTAC degrader
|
MS98 (AKT PROTAC degrader) is a potent, selective von Hippel-Lindau (VHL)-recruiting AKT PROTAC degrader with DC50 of 78 nM. |
