| Cat. No. |
Product Name |
Information |
| PC-24083 |
SK2188
Aurora A PROTAC
|
SK2188 is a potent, highly selective PROTAC degrader of Aurora A with DC50 of 3.9 nM and Dmax of 89% in NGP neuroblastoma cells, induces subsequent reduction of MYCN. |
| PC-24082 |
JB170
Aurora A PROTAC
|
JB170 is a potent, highly selective PROTAC degrader of Aurora A with DC50 of 28 nM and Dmax of 300 nM in MV4-11 cells, linking alisertib to the cereblon-binding molecule Thalidomide. |
| PC-24081 |
JB300
Aurora A PROTAC
|
JB300 is a potent, highly selective PROTAC degrader of Aurora A with DC50 of 30 nM. |
| PC-24047 |
KT-333
STAT3 degrader
|
KT-333 (KT333) is a potent, highly specific potent heterobifunctional PROTAC degrader of STAT3 with DC50 of 2.5 -11.8 nM in anaplastic T cell lymphoma (ALCL) lines. |
| PC-24046 |
CDK9 PROTAC C3
CDK9 degrader
|
CDK9 PROTAC C3 is a potent and selective, oral CDK9 PROTAC degrader with DC50 of 1.09 nM in NCI-H69 cells. |
| PC-23960 |
QXG-6442
CK1α PROTAC
|
QXG-6442 is a potent, selective casein kinase 1 alpha (CK1α) degrader with DC50 value of 5.7 nM and Dmax of 90% in in MOLT-4 cells. |
| PC-23948 |
TD-522
GSPT1 degrader
|
TD-522 is a potent, selective GSPT1 degrader, ffectively induces GSPT1 degradation with DC50 of 0.269 nM and Dmax of >95 % at 10 nM in KG-1 cells. |
| PC-23947 |
AN5777
GSPT1 degrader
|
AN5777 is a potent GSPT1 degrader, binds recombinant CRBN and induces GSPT1 degradation through the UPS. |
| PC-23946 |
LYG-409
GSPT1 degrader
|
LYG-409 is a potent, selective, and orally bioavailable GSPT1 molecular glue degrader with DC50 of 7.87 nM in KG-1 cells. |
| PC-23899 |
AH078
CK1δ /CK1ε PROTAC
|
AH078 is a potent, highly selective PROTAC degrader of CK1δ and CK1ε with DC50 of 200 nM (CK1δ) in HEK293 cells, shows excellent selectivity over the highly related CK1α isoform. |
| PC-23854 |
HDAC6 PROTAC A6
HDAC6 PROTAC
|
HDAC6 PROTAC A6 is a potent, selective HDAC6 PROTAC degrader with DC50 of 3.5 nM, Dmax values of over 80% in HL-60 cells. |
| PC-23853 |
FF2049
HDAC1-3 PROTAC
|
FF2049 is a first-in-class, selective Fem-1 homologue B (FEM1B)-recruiting HDAC1-3 PROTAC degrader with DC50 value of 257 nM and Dmax of 85% (HDAC1) in MM.1S cells. |
