JH-XII-03-02

Chemical Structure : JH-XII-03-02

Catalog No.: PC-21068Not For Human Use, Lab Use Only.

JH-XII-03-02 is a highly potent, selective PROTAC degrader of LRRK2 with IC50 of 1 nM against both wt LRRK2 and LRRK2 G2019S.

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Biological Activity

JH-XII-03-02 is a highly potent, selective PROTAC degrader of LRRK2 with IC50 of 1 nM against both wt LRRK2 and LRRK2 G2019S.
JH-XII-03-02 displays high potency and remarkable selectivity for LRKK2 when assessed in a of 468 panel kinases.
JH-XII-03-02 shows potent degradation of LRRK2 following 48hr treatment of LRRK2 wt and LRRK2 R144C MEF cells at a concentration of 1 µM.
JH-XII-03-02 significantly inhibits phosphorylation of S935 and Rab10.

Physicochemical Properties

M.Wt	853.93
Formula	C43H51N9O10
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES

References

1. John M Hatcher, et al. Bioorg Med Chem Lett. 2023 Aug 15;129449.

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JH-XII-03-02

Biological Activity

Physicochemical Properties

References

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