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Chemical Structure : JH-XII-03-02
Catalog No.: PC-21068Not For Human Use, Lab Use Only.
JH-XII-03-02 is a highly potent, selective PROTAC degrader of LRRK2 with IC50 of 1 nM against both wt LRRK2 and LRRK2 G2019S.
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JH-XII-03-02 is a highly potent, selective PROTAC degrader of LRRK2 with IC50 of 1 nM against both wt LRRK2 and LRRK2 G2019S.
JH-XII-03-02 displays high potency and remarkable selectivity for LRKK2 when assessed in a of 468 panel kinases.
JH-XII-03-02 shows potent degradation of LRRK2 following 48hr treatment of LRRK2 wt and LRRK2 R144C MEF cells at a concentration of 1 µM.
JH-XII-03-02 significantly inhibits phosphorylation of S935 and Rab10.
| M.Wt | 853.93 | |
| Formula | C43H51N9O10 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. John M Hatcher, et al. Bioorg Med Chem Lett. 2023 Aug 15;129449.
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