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Cat. No. Product Name Information
PC-21126

ARD-2128

AR PROTAC

ARD-2128 is a potent, orally active PROTAC androgen receptor (AR) degrader with DC50 of 0.28 nM in CcaP cell line.
PC-21125

ARD-2585

AR PROTAC

ARD-2585 is a potent and orally bioavailable PROTAC androgen receptor (AR) degrader with DC50 of 0.04 nM, Dmax=99% in VCaP cell line.
PC-21124

MTX-23

AR PROTAC

MTX-23 is a proteolysis targeting chimera (PROTAC) degrader of androgen receptor (AR) splice variant-7 (AR-V7) and AR-full length (AR-FL) with DC50 of 0.37 and 2 uM, respectively.
PC-21123

BWA-522

AR PROTAC

BWA-522 is a potent, orally bioavailable PROTAC degrader of the androgen receptor N-terminal domain (AR-NTD), induces AR-FL or AR-V7 protein degradationwith DC50 of 0.73 μM (AR-FL) and 0.67 μM (AR-V7) in VCaP cells.
PC-21116

PDCD2 degrader 10e

PDCD2 PROTAC

PDCD2 degrader 10e is a first-in-class small molecule degrader of programmed cell death 2 (PDCD2), induces PDCD2 degradation in a dose-dependent manner with DC50 value of 2 nM (MOLT-4 cells, 24 h, Emax=96.7%), shows highproteome-wide selectivity.
PC-21068

JH-XII-03-02

LRRK2 PROTAC

JH-XII-03-02 is a highly potent, selective PROTAC degrader of LRRK2 with IC50 of 1 nM against both wt LRRK2 and LRRK2 G2019S.
PC-21045

KYH1872

PROTAC

KYH1872 is a PROTAC that induces protein degradation via the KLHDC2 E3 ubiquitin ligase, KYH1872 is consisted of a C-terminal fragment of the SelK protein and promiscuous kinase inhibitor YHJ1039 via PGE linker.
PC-21044

DB0614

PROTAC

DB0614 is a CRBN-based PROTAC, induces the degradation of NEK9, FAK, CDK4, CDK6, and WEE1 in cells.
PC-20816

PTD10

BTK PROTAC

PTD10 is a highly potent BTK PROTAC degrader with DC50 of 0.5 nM in TMD8 cells, inhibits cell growth and induces apoptosis more potently than parent molecule GDC-0853.
PC-20680

MRT-2359

GSPT1 PROTAC

MRT-2359 (MRT2359) is a potent, selective and orally bioavailable GSPT1-directed molecular glue degrader with DC50 of 5 nM in CAL51 cell line (Dmax=100%).
PC-20653

DeFer-2

Ferritin PROTAC

DeFer-2 is an oleic acid (OA)-based ferritin-targeting PROTAC binding Kd of 17.1 uM, degrades ferritin and rapidly elevates the free iron content, induces pyroptosis.
PC-20565

CP5V

Cdc20 PROTAC

CP5V (apcin-A-PEG5-VHL Ligand 1) is an efficient, selective Cdc20 PROTAC with DC50 of 1.6 uM in both MCF7 and MDA-MB-231 cells, induces mitotic inhibition and suppresses cancer cell proliferation.

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