| Cat. No. |
Product Name |
Information |
| PC-60103 |
BETd-260 trifluoroacetate
BET PROTAC
|
BETd-260 trifluoroacetate (ZBC260, BETd 260 TFA) is a novel PROTAC BET degrader that tether HJB97 to a ligand for the E3 ubiquitin ligase VHL. |
| PC-60102 |
BETd-260
BET PROTAC
|
BETd-260 (ZBC260, BETd260) is a novel PROTAC BET degrader that tether HJB97 to a ligand for the E3 ubiquitin ligase VHL. |
| PC-60100 |
CDK9 PROTAC 1
CDK9 PROTAC
|
CDK9 PROTAC 1 is a heterobifunctional small molecule PROTAC capable of cereblon mediated proteasomal degradation of CDK9. |
| PC-60099 |
MZ1
BRD4 PROTAC
|
MZ1 is a PROTAC that tethers JQ1 to a ligand for the E3 ubiquitin ligase VHL, triggers and induces degradation of the BET bromodomain BRD4. |
| PC-60096 |
Sirt2 PROTAC 1
Sirt2 PROTAC
|
Sirt2 PROTAC 1 is a SirReal-based PROTAC that induces isotype-selective Sirt2 degradation (IC50=0.25 uM). |
| PC-42297 |
ARV-771
BET PROTAC
|
ARV-771 (ARV771) is a potent BET degrader (PROTAC), potently degrades BRD2/3/4 in 22Rv1 cells with DC50< 5 nM. |
| PC-45097 |
ARV-825
BRD4 PROTAC
|
ARV-825 is a hetero-bifunctional PROTAC (Proteolysis Targeting Chimera) that recruits BRD4 to the E3 ubiquitin ligase cereblon, leading to fast, efficient, and prolonged degradation of BRD4 via the proteasome. |
| PC-27930 |
NUP214 degrader 0449-b
NUP214 degrader
|
NUP214 degrader 0449-b is a selective nucleoporin NUP214 degrader by recruiting NUP214 to the Cullin5-Rbx2 E3 ligase complex, induces NUP214 neddylation and proteasomal degradation, triggers leukemia stem cells (LSCs) ferroptosis and exhibits anti-leukemic activity, while sparing normal hematopoietic stem cells. |
| PC-27878 |
DnAurA-A10
AURKA PROTAC
|
DnAurA-A10 is a selective, nuclear-targeted PROTAC degrader of Aurora kinase A (AURKA), induces nuclear AURKA degradation at 10-50 uM in HCT116 cells. |
| PC-27854 |
dBAZ2
BAZ2A/B PROTAC
|
dBAZ2 is a first-in-class Proteolysis Targeting Chimera (PROTAC) degrading BAZ2A/B, selectively degrades BAZ2A and BAZ2B with DC50 of 180 nM and 250 nM, and Dmax ≥ 97% in PC3 cells. |
| PC-27853 |
dBAZ2B
BAZ2B PROTAC
|
dBAZ2B is a first-in-class Proteolysis Targeting Chimera (PROTAC) degrading BAZ2B, selectively degrades BAZ2B with DC50 of 19 nM and Dmax ≥ 97% in PC3 cells, does not affect BAZ2A. |
| PC-27685 |
DB-0646
Multi-target PROTAC
|
DB-0646 is a multi-target PROTAC degrader that degrades over a panel of 125 distinct kinases in various cell lines, induces ubiquitination and degradation of GCK, BUB1 and YES1. |
