| Cat. No. |
Product Name |
Information |
| PC-23554 |
YZ-836P
PRMT5 PROTAC
|
YZ-836P is a CRBN-recruiting PRMT5 PROTAC degrader, exerts cytotoxic effects in TNBC, promotes the ubiquitination and degradation of PRMT5 in a CRBN-dependent manner, downregulates key downstream target protein KLF5 in TNBC. |
| PC-23543 |
dCK1α-2
CK1α degrader
|
dCK1α-2 is a potent, selective and orally bioavailable CK1α degrader with DC50 of 146 nM, Dmax of 84% in MOLM13 cells. |
| PC-23542 |
dCK1α-1
CK1α degrader
|
dCK1α-1 (LC-04-087) is a potent and selective CK1α-targeting molecular glue degrader with DC50 of 12 nM, Dmax of 90% in MOLM13 cells (72 h). |
| PC-23448 |
ATC-324
AR AUTOTAC degrader
|
ATC-324 is a potent, selective androgen receptor (AR) AUTOphagy-TArgeting Chimera (AUTOTAC) degrader with DC50 of 2.05 uM in LNCaP cells, induces the formation of the AR/p62 complex, leading to autophagy-lysosomal degradation of AR. |
| PC-23445 |
TRIB2 PROTAC 5k
TRIB2 PROTAC
|
TRIB2 PROTAC 5k (Compound 5k) is a potent, selective pseudokinase TRIB2 PROTAC degrader with DC50 of 16.8 nM and Dmax of 92% in PC3 cells. |
| PC-23413 |
WIZ degrader 10
WIZ degrader
|
WIZ degrader 10 is a potent, and selective molecular glue degrader of the transcription factor WIZ with DC50 of 3 nM and Dmax of 86%. |
| PC-23400 |
WEE1-CK1α molecular glue degrader 10
WEE1/CK1α degrader
|
WEE1-CK1α molecular glue degrader 10 is a CRBN-dependent WEE1 molecular glue degrader that degrade WEE1 and CK1α with DC50 of 1.6 nM and 1.5 nM in MOLT-4 cells respectively. |
| PC-23399 |
WEE1-CK1α molecular glue degrader 1
WEE1/CK1α degrader
|
WEE1-CK1α molecular glue degrader 1 is a CRBN-dependent WEE1 molecular glue degrader that degrade WEE1 and CK1α with DC50 of 1.1 nM and 3.4 nM in MOLT-4 cells respectively. |
| PC-23385 |
MD-265
MDM2 PROTAC
|
MD-265 is a potent PROTAC MDM2 degrader, potently inhibits RS4;11 cell line with IC50 of 0.7 nM, induces strong p53 activation in cancer cells carrying wild-type p53. |
| PC-23329 |
BRD9 PROTAC C6
BRD9 PROTAC
|
BRD9 PROTAC C6 is a potent, selective and orally active BRD9 PROTAC degrader with DC50 of 1.02 nM in MV4-11 cells (24 h), without effect on BRD4 or BRD7. |
| PC-23323 |
BET PROTAC SIM1
BRD2 PROTAC
|
BET PROTAC SIM1 is a highly potent, von Hippel-Lindau (VHL)-based BET trivalent PROTAC degrader with preference for BRD2 with DC50 of 1.1 nM, 3.3 nM and 0.7 nM for RD2, BRD3, BRD4 in HEK293 cells, potently inhibits cell viability of MV4;11 AML cell line with IC50 of 1.1 nM (48 h). |
| PC-23305 |
pan-KRAS degrader 4
pan-KRAS PROTAC
|
pan-KRAS degrader 4 is a potent, selective, reversible heterobifunctional pan-KRAS PROTAC degrader with Dmax50 of 17 nM in GP5d cells, efficiently degrades 13 of the 17 most prevalent KRAS mutant alleles and KRASWT with single-digit nanomolar potency. |
