Chemical Structure : LD5095
CAS No.:
LD5095
(LD-5095)
Catalog No.: PC-26648Not For Human Use, Lab Use Only.
LD5095 is a potent, selective cereblon (CRBN)-recruiting RIPK1 degrader with DC50 of 1.4, 1.2, and 2.3 nM and Dmax>90% for endogenous RIPK1 in WT Jurkat, MOLM14, and U937 cell lines.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
LD5095 is a potent, selective cereblon (CRBN)-recruiting RIPK1 degrader with DC50 of 1.4, 1.2, and 2.3 nM and Dmax>90% for endogenous RIPK1 in WT Jurkat, MOLM14, and U937 cell lines.
LD5095 achieves maximal RIPK1 degradation at 200 nM, reaching Dmax values of 94% in Jurkat cells, 95% in MOLM14 cells, and 91% in U937 cells.
LD5095 induces RIPK1 degradation which is strictly dependent on the specific recruitment of the CRBN E3 ligase and the subsequent activation of the entire ubiquitin-proteasome system (UPS) cascade in Jurkat cells.
LD5095 sensitizes Jurkat cells to TNFα-mediated apoptosis.
LD5095 exhibits negligible activity in murine B16F10 cells.
Physicochemical Properties
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M.Wt
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1165.29
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Formula
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C65H63F3N12O6
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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3-((4-(1-(2-(6-(5-((4-(4-(4-amino-5-(1-(2-(3-(trifluoromethoxy)phenyl)acetyl)indolin-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)piperidine-1-carbonyl)phenyl)ethynyl)pyridin-2-yl)-2,6-diazaspiro[3.3]heptan-2-yl)-2-oxoethyl)piperidin-4-yl)phenyl)amino)piperidine-2,6-dione
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References
1. Lu D, et al. bioRxiv [Preprint]. 2026 Apr 14:2026.04.10.717852.
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