| Cat. No. |
Product Name |
Information |
| PC-22558 |
2-12-2-deg
Flaviviruse E protein PROTAC
|
2-12-2-deg is a PROTAC targeting the dengue virus (DENV) envelope (E) protein with DC50 of 0.21 uM, Dmax of 95%, depletes intracellular E via a CRBN- and proteasome-dependent mechanism. |
| PC-22554 |
ARCC-4
AR degrader
|
ARCC-4 is a potent, selective enzalutamide-based von Hippel-Lindau (VHL)-recruiting androgen receptor (AR) degrader with DC50 of 5 nM in VCaP cells. |
| PC-22553 |
UBX-390
AR degrader
|
UBX-390 is a potent, selective cereblon (CRBN)-based androgen receptor (AR) degrader with DC50 of 2.41 nM in VCaP cells. |
| PC-22538 |
SIAIS039
ROS1 PROTAC
|
SIAIS039 is the first ROS1-specific PROTAC degrader with DC50 of 154.46 nM in HCC78 cells, shows cytotoxic effects in cells carrying ROS1 fusion mutations. |
| PC-22535 |
KI-CDK9d-32
CDK9 degrader
|
KI-CDK9d-32 is a highly potent and selective CDK9 degrader with DC50 of 0.89 nM in MOLT-4 cells (4h) and Dmax of 97.7%, induces rapid reduction of MYC protein levels. |
| PC-22505 |
ZXH-8-004
DENV E protein degrader
|
ZXH-8-004 is a selective and potent PROTAC degrader of the envelope (E) protein of dengue virus (DENV), demonstrates potent antiviral activity.
ZXH-8-004 is cell permeable and able to engage the CRL4CRBN E3 ligase. |
| PC-22493 |
FAK degrader F2
FAK degrader
|
FAK PROTAC F2 is a potent, selective FAK CRBN-recruiting PROTAC degrader based on the FAK inhibitor Ifebemtinib (IN10018) with DC50 of 27.72 nM and 60.10 nM for total FAK and phosphorylated FAK in MDA-MB-231 cells. |
| PC-22486 |
XYD129
CBP/p300 degrader
|
XYD129 is a highly potent and selective CBP/p300 degrader with IC50 of 21/30 nM, effectively degrades CBP/p300 proteins and exhibits potent inhibition of growth in acute leukemia cell lines (MOLM-16, IC50=7.4 nM). |
| PC-22441 |
ARM165
PIK3CG/p110γ degrader
|
ARM165 is a proteolysis-targeting chimera (PROTAC) heterobifunctional molecule that specifically degrades PIK3CG/p110γ, specifically degrades PIK3CG and potently suppresses AML. |
| PC-22429 |
R1-ICR-5
RIPK1 degrader
|
R1-ICR-5 is a selective and potent RIPK1 PROTAC degrader, triggers VHL-mediated degradation of RIPK1, deregulates TNFR1 and TLR3 signaling, enhances innate immune signaling and necroptosis |
| PC-22413 |
AN2
mHTT degrader
|
AN2 is a alkenyl oxindole molecular glue that tether mHTT to LC3, enabling the lysosomal degradation of mHTT. |
| PC-22412 |
AN1
mHTT degrader
|
AN1 is a alkenyl oxindole molecular glue that tether mHTT to LC3, enabling the lysosomal degradation of mHTT. |
