Catalog No.: PC-20565Not For Human Use, Lab Use Only.
CP5V (apcin-A-PEG5-VHL Ligand 1) is an efficient, selective Cdc20 PROTAC with DC50 of 1.6 uM in both MCF7 and MDA-MB-231 cells, induces mitotic inhibition and suppresses cancer cell proliferation.
CP5V (apcin-A-PEG5-VHL Ligand 1) is an efficient, selective Cdc20 PROTAC with DC50 of 1.6 uM in both MCF7 and MDA-MB-231 cells, induces mitotic inhibition and suppresses cancer cell proliferation. CP5V-induced degradation of Cdc20 is mediated through the ubiquitin-proteasome pathway. CP5V-induced Cdc20 degradation is sensitive to neddylation inhibitor MLN4924. CP5V efficiently binds onto Cdc20 (SOR KD=11.2 uM) to help stabilize Cdc20-PROTACS-VHL-ElonginC-ElonginB complex. CP5V significantly inhibits mitotic progression and induces breast cancer cell death. CP5V restores Taxol-induced cytotoxic response in Taxol-resistant cells. CP5V is a potent inhibitor that suppresses breast tumor progression with no toxicity in 4T1 xenograft model.
