| Cat. No. |
Product Name |
Information |
| PC-21526 |
TMX-2172
CDK2/5 PROTAC
|
TMX-2172 is a potent, selective CDK2 and CDK5 dual PROTAC degrader with IC50 of 6.5 nM and 6.8 nM for CDK2/cyclin A and CDK5/p25, respectively. |
| PC-21424 |
XY-07-35
HDAC6 PROTAC
|
XY-07-35 is a potent, selective HDAC6 proteolysis targeting chimera (PROTAC) degrader with IC50 of 48.5 nM. |
| PC-21336 |
SelDeg51
FKBP51 PROTAC
|
SelDeg51 (Selective Degrader of FKBP51) is a potent, selective FKBP51 PROTAC with Kd of 18 nM, Emax=90%. |
| PC-21276 |
JWZ-1-80
PI5P4Kγ PROTAC
|
JWZ-1-80 is a potent and selective PROTAC degrader of PI5P4Kγ with Kd of 510 nM, 1 uM induces 75% reduction of PI5P4Kγ in Molt4 cells. |
| PC-21161 |
ARD-2051
AR PROTAC
|
ARD-2051 (ARD-2051) is a potent and orally efficacious androgen receptor (AR) proteolysis-targeting chimera (PROTAC) degrader with DC50 of 0.6 nM in AR+ VCaP and LNCaP cell lines. |
| PC-21160 |
ARD-1676
AR PROTAC
|
ARD-1676 (ARD1676) is a highly potent and orally efficacious PROTAC degrader of the androgen receptor (AR) with DC50 values of 0.1 and 1.1 nM in AR+ VCaP and LNCaP cell lines, respectively. |
| PC-21127 |
TD-802
AR PROTAC
|
TD-802 is potent, cereblon-mediated androgen receptor PROTAC degrader, effectively inducs AR protein degradation with DC50 of 12.5 nM and Emax 93% in LNCaP prostate cancer cells. |
| PC-21126 |
ARD-2128
AR PROTAC
|
ARD-2128 is a potent, orally active PROTAC androgen receptor (AR) degrader with DC50 of 0.28 nM in CcaP cell line. |
| PC-21125 |
ARD-2585
AR PROTAC
|
ARD-2585 is a potent and orally bioavailable PROTAC androgen receptor (AR) degrader with DC50 of 0.04 nM, Dmax=99% in VCaP cell line. |
| PC-21124 |
MTX-23
AR PROTAC
|
MTX-23 is a proteolysis targeting chimera (PROTAC) degrader of androgen receptor (AR) splice variant-7 (AR-V7) and AR-full length (AR-FL) with DC50 of 0.37 and 2 uM, respectively. |
| PC-21116 |
PDCD2 degrader 10e
PDCD2 PROTAC
|
PDCD2 degrader 10e is a first-in-class small molecule degrader of programmed cell death 2 (PDCD2), induces PDCD2 degradation in a dose-dependent manner with DC50 value of 2 nM (MOLT-4 cells, 24 h, Emax=96.7%), shows highproteome-wide selectivity. |
| PC-21068 |
JH-XII-03-02
LRRK2 PROTAC
|
JH-XII-03-02 is a highly potent, selective PROTAC degrader of LRRK2 with IC50 of 1 nM against both wt LRRK2 and LRRK2 G2019S. |
