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TMX-4116

Chemical Structure : TMX-4116

CAS No.: 2766385-56-0

TMX-4116 (TMX4116)

Catalog No.: PC-20151Not For Human Use, Lab Use Only.

TMX-4116 (TMX4116) is a highly potent casein kinase 1α (CK1α) degrader with DC50 of <200 nM (CK1α) in MOLT4 cells, does not degrade PDE6D and IKZF1/IKZF3.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    TMX-4116 (TMX4116) is a highly potent casein kinase 1α (CK1α) degrader with DC50 of <200 nM (CK1α) in MOLT4 cells, does not degrade PDE6D and IKZF1/IKZF3.

    Physicochemical Properties

    M.Wt 389.43
    Formula C17H19N5O4S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    3-[4-[4-Methoxy-5-(1-pyrrolidinylcarbonyl)-3-thienyl]-1H-1,2,3-triazol-1-yl]-2,6-piperidinedione

    References

    1. Mingxing Teng, et al. J Med Chem. 2022 Jan 13;65(1):747-756.

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