| Cat. No. |
Product Name |
Information |
| PC-35215 |
dBET57
BRD4 BD1 PROTAC
|
dBET57 is a novel BRD4 heterobifunctional small-molecule ligand (PROTAC), exhibits significant and selective degradation of BRD4 BD1 (DC50/5h=500 nM), but is inactive on BRD4 BD2.. |
| PC-35214 |
dBET23
BRD4 PROTAC
|
dBET23 is a highly effective BRD4 PROTAC degrader, exhibits significant and selective degradation of BRD4 BD1 (DC50/5h=50 nM) in cellular degradation assays. |
| PC-35213 |
MT-802
BTK PROTAC
|
MT-802 (MT802) is a potent BTK PROTAC degrader that induces degradation of both wild-type and C481S mutant BTK (DC50=9.1 nM). |
| PC-35204 |
ZXH-3-26
BRD4 BD1 PROTAC
|
ZXH-3-26 is a novel BRD4 heterobifunctional small-molecule ligand (PROTAC), shows activity exclusively on the BRD4 BD1 (DC50/5h=5 nM) and spares degradation of BRD2 or BRD3 in cellular degradation assays. |
| PC-35152 |
TL13-112
|
TL13-112 is a novel Anaplastic Lymphoma Kinase (ALK)-PROTAC developed through conjugation of LDK378 and the cereblon ligand pomalidomide. |
| PC-35151 |
TL13-12
ALK PROTAC
|
TL13-12 is a novel Anaplastic Lymphoma Kinase (ALK)-PROTAC developed through conjugation of TAE684 and the cereblon ligand pomalidomide. |
| PC-35090 |
SNIPER(ER)-110
ERα degrader
|
SNIPER(ER)-110 is a nongenetic IAP-dependent protein eraser (SNIPER) targeting estrogen receptor α (ERα), induces ERα degradation and induces apoptosis in MCF-7 human breast cancer cells. |
| PC-35040 |
PAC1
ERα PROTAC
|
PAC1 (Compound PAC1) is a novel PROTAC antibody conjugate, more potent estrogen receptor-alpha (ERα) degrader compared to PROTAC without antibody conjugation.. |
| PC-35017 |
IBET151-VHL-PROTAC
BET PROTAC
|
IBET151-VHL-PROTAC is a novel PROTAC.. |
| PC-35013 |
JQ1-VHL-PROTAC
|
JQ1-VHL-PROTAC is a novel PROTAC synthesis.. |
| PC-63529 |
MS4077
ALK PROTAC
|
MS4077 is a novel PROTAC (degrader) of ALK, potently decreases cellular levels of oncogenic active ALK fusion proteins in a concentration- and time-dependent manner in SU-DHL-1 lymphoma and NCI-H2228 lung cancer cells (DC50=3 nM). |
| PC-63528 |
MS4078
ALK PROTAC
|
MS4078 is a novel PROTAC (degrader) of ALK, potently decreases cellular levels of oncogenic active ALK fusion proteins in a concentration- and time-dependent manner in SU-DHL-1 lymphoma and NCI-H2228 lung cancer cells (DC50=11 nM). |
