| Cat. No. |
Product Name |
Information |
| PC-35040 |
PAC1
ERα PROTAC
|
PAC1 (Compound PAC1) is a novel PROTAC antibody conjugate, more potent estrogen receptor-alpha (ERα) degrader compared to PROTAC without antibody conjugation.. |
| PC-35017 |
IBET151-VHL-PROTAC
BET PROTAC
|
IBET151-VHL-PROTAC is a novel PROTAC.. |
| PC-35013 |
JQ1-VHL-PROTAC
|
JQ1-VHL-PROTAC is a novel PROTAC synthesis.. |
| PC-63529 |
MS4077
ALK PROTAC
|
MS4077 is a novel PROTAC (degrader) of ALK, potently decreases cellular levels of oncogenic active ALK fusion proteins in a concentration- and time-dependent manner in SU-DHL-1 lymphoma and NCI-H2228 lung cancer cells (DC50=3 nM). |
| PC-63528 |
MS4078
ALK PROTAC
|
MS4078 is a novel PROTAC (degrader) of ALK, potently decreases cellular levels of oncogenic active ALK fusion proteins in a concentration- and time-dependent manner in SU-DHL-1 lymphoma and NCI-H2228 lung cancer cells (DC50=11 nM). |
| PC-63465 |
JH-XI-10-02
CDK8 PROTAC
|
JH-XI-10-02 is a CDK8 PROTAC based on the CDK8 inhibitor JH-VIII-49, induces partial degradation of CDK8 in Jurkat cells with IC50 of 159 nM. |
| PC-63217 |
dTRIM24
TRIM24 PROTAC
|
dTRIM24 is a potent and selective, bifunctional PROTAC degrader of TRIM24 with IC50 of 337.7 nM in TRIM24 ligand displacement assay. |
| PC-62321 |
dBET1
BET PROTAC
|
dBET1 is a proteolysis-targeting chimera (PROTAC) molecule that appendes a competitive antagonist of BET bromodomain (JQ1) to a phthalimide moiety to hijack the cereblon E3 ubiquitin ligase complex. |
| PC-61699 |
dBET6
BET PROTAC
|
dBET6 is a highly potent, cell-permeable, optimized chemical degrader of BET bromodomain BRD4 with IC50 of 14 nM. |
| PC-60931 |
BETd-246
BET PROTAC
|
BETd-246 (BETd246) is a potent, second-generation BET protein PROTAC degrader that exhibits superior selectivity, potency and antitumor activity. |
| PC-60484 |
TBK1 PROTAC 1
TBK1 PROTAC
|
TBK1 PROTAC 1 (Compound 3i) is a potent, selective TBK1 PROTAC with DC50 of 12 nM, selectively degrades TBK1 with excellent selectivity against a related kinase IKKε. |
| PC-60330 |
THAL-SNS-032
CDK9 degrader
|
THAL-SNS-032 is a novel CDK9 degrader PROTAC consisting of a CDK-binding SNS-032 ligand linked to a thalidomide derivative that binds the E3 ubiquitin ligase Cereblon (CRBN). |
