| Cat. No. |
Product Name |
Information |
| PC-24081 |
JB300
Aurora A PROTAC
|
JB300 is a potent, highly selective PROTAC degrader of Aurora A with DC50 of 30 nM. |
| PC-24058 |
RDN8011
KDM4 PROTAC
|
RDN8011 is a potent, selective first-in-class PROTAC degrader of KDM4 with DC50 of 37-50 nM for KDM4A/KDM4B/KDM4C in in KYSE-150 cells, while sparing KDM4D. |
| PC-24047 |
KT-333
STAT3 degrader
|
KT-333 (KT333) is a potent, highly specific potent heterobifunctional PROTAC degrader of STAT3 with DC50 of 2.5 -11.8 nM in anaplastic T cell lymphoma (ALCL) lines. |
| PC-24046 |
CDK9 PROTAC C3
CDK9 degrader
|
CDK9 PROTAC C3 is a potent and selective, oral CDK9 PROTAC degrader with DC50 of 1.09 nM in NCI-H69 cells. |
| PC-24021 |
NRX-0492
BTK PROTAC
|
NRX-0492 is a potent, selective cereblon (CRBN)-basesd PROTAC degrader of wild-type and C481 mutant BTK with DC50 of 0.1 nM and 0.2 nM, and DC90 of 0.3 nM and 0.5 nM in TMD8 cells expressing WT or C481S mutant BTK respectively. |
| PC-23963 |
DEG-77
IKZF2/CK1α degarder
|
DEG-77 is a more soluble analog of DEG-35, dual degrader of IKZF2 and casein kinase 1α (CK1α) with DC50 of 15.3 nM and 10 nM respectively. |
| PC-23962 |
CC-91633
CK1α PROTAC
|
CC-91633 (BMS-986397) is a first-in-class, potent and selective CRBN-based molecular glue degrader of casein Kinase 1α (CK1α). |
| PC-23961 |
DEG-35
IKZF2/CK1α degarder
|
DEG-35 is a potent, cereblon-dependent, dual degrader of IKZF2 ((DC50=4.4 nM, DCmax=92%)) and casein kinase 1α (CK1α, DC50=1.4 nM, DCmax=84%), shows leukemic cell killing activity. |
| PC-23960 |
QXG-6442
CK1α PROTAC
|
QXG-6442 is a potent, selective casein kinase 1 alpha (CK1α) degrader with DC50 value of 5.7 nM and Dmax of 90% in in MOLT-4 cells. |
| PC-23948 |
TD-522
GSPT1 degrader
|
TD-522 is a potent, selective GSPT1 degrader, ffectively induces GSPT1 degradation with DC50 of 0.269 nM and Dmax of >95 % at 10 nM in KG-1 cells. |
| PC-23947 |
AN5777
GSPT1 degrader
|
AN5777 is a potent GSPT1 degrader, binds recombinant CRBN and induces GSPT1 degradation through the UPS. |
| PC-23946 |
LYG-409
GSPT1 degrader
|
LYG-409 is a potent, selective, and orally bioavailable GSPT1 molecular glue degrader with DC50 of 7.87 nM in KG-1 cells. |
