Catalog No.: PC-38302Not For Human Use, Lab Use Only.
Helios degrader ALV1 (ALV-03-112-01) is a small molecule degrader of the zinc-finger transcription factor Helios with IC50 of 0.55 uM in CRBN-binding TR-FRET assay, exhibits similar degradation activity towards IKZF1/2/3.
Helios degrader ALV1 (ALV-03-112-01) is a small molecule degrader of the zinc-finger transcription factor Helios with IC50 of 0.55 uM in CRBN-binding TR-FRET assay, exhibits similar degradation activity towards IKZF1/2/3.
ALV1 recruits the E3 ubiquitin ligase substrate receptor cereblon to Helios.
ALV1 bound CRBN in vitro with greater potency than lenalidomide but less than CC-885.
ALV1 also induced CRBN-Helios dimerization in the TR-FRET assay, with greater activity than either CC-885. ALV1 degraded both Ikaros and Helios.
