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dBRD9-A

Chemical Structure : dBRD9-A

CAS No.: 2170679-42-0

dBRD9-A (dBRD 9-A)

Catalog No.: PC-72322Not For Human Use, Lab Use Only.

dBRD9-A is a chemical degrader (PROTAC) of BRD9, a highly specific binder of the BRD9 bromodomain and elicits near complete BRD9 degradation at low nanomolar concentrations.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    dBRD9-A is a chemical degrader (PROTAC) of BRD9, a highly specific binder of the BRD9 bromodomain and elicits near complete BRD9 degradation at low nanomolar concentrations.
    dBRD9-A blocks synovial sarcoma tumour progression and oncogenic transcription.
    dBRD9-A limited IFN‐induced expression of certain ISGs in multiple cell types, significantly reduced induction of 29 ISGs, including many ISGs known to harbor antiviral activity against the viruses, such as MX1, MX2, IFITM1, IFITM3, IDO1, and BST2.

    Physicochemical Properties

    M.Wt 779.895
    Formula C42H49N7O8
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    Acetamide, 2-[[[4-(1,2-dihydro-2-methyl-1-oxo-2,7-naphthyridin-4-yl)-2,6-dimethoxyphenyl]methyl]methylamino]-N-[8-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]octyl]-

    References

    1. Gerard L Brien, et al. Elife. 2018 Nov 15;7:e41305.

    2. Jacob Börold, et al. EMBO Rep. 2021 Oct 5;22(10):e52823.

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