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Chemical Structure : HPK1 PROTAC SS47
Catalog No.: PC-72308Not For Human Use, Lab Use Only.
HPK1 PROTAC SS47 is a heterobifunctional small molecule based on ZYF0033 that simultaneously binds HPK1 and E3 ligase Cereblon (CRBN), induces degradation of HPK1.
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HPK1 PROTAC SS47 is a heterobifunctional small molecule HPK1 degrader based on ZYF0033 that simultaneously binds HPK1 and E3 ligase Cereblon (CRBN), induces degradation of HPK1.
SS47 exerts proteasome-mediated HPK1 degradation within 48 h of treatment, SS47 (100 nM) induced HPK1 degradation in bone-marrow-derived DCs, significantly increased the proliferation of CD4+ and CD8+ T cells and the secretion of IFN-γ.
SS47 showed markedly better inhibition of tumor growth than either ZYF0033 or the ddH2O control in mice with subcutaneous 4T-1 tumors.
| M.Wt | 953.077 | |
| Formula | C49H56N6O12S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Jingwen Si, et al. Cancer Cell. 2020 Oct 12;38(4):551-566.e11.
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