Catalog No.: PC-72308Not For Human Use, Lab Use Only.
HPK1 PROTAC SS47 is a heterobifunctional small molecule based on ZYF0033 that simultaneously binds HPK1 and E3 ligase Cereblon (CRBN), induces degradation of HPK1.
HPK1 PROTAC SS47 is a heterobifunctional small molecule HPK1 degrader based on ZYF0033 that simultaneously binds HPK1 and E3 ligase Cereblon (CRBN), induces degradation of HPK1.
SS47 exerts proteasome-mediated HPK1 degradation within 48 h of treatment, SS47 (100 nM) induced HPK1 degradation in bone-marrow-derived DCs, significantly increased the proliferation of CD4+ and CD8+ T cells and the secretion of IFN-γ.
SS47 showed markedly better inhibition of tumor growth than either ZYF0033 or the ddH2O control in mice with subcutaneous 4T-1 tumors.
