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Chemical Structure : MS934
Catalog No.: PC-72324Not For Human Use, Lab Use Only.
MS934 (MS-934) is a VHL-recruiting MEK1/2 degrader (PROTAC) with HT29 DC50 of 18/9 nM for MEK1/2 degradation, respectively.
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MS934 (MS-934) is a VHL-recruiting MEK1/2 degrader (PROTAC) with HT29 DC50 of 18/9 nM for MEK1/2 degradation, respectively.
MS934 displays antiproliferation potency against HT29 cell with GI50 of 23 nM, degrades MEK1 and MEK2 and inhibits pMEK and pERK in a concentration-dependent manner in HT-29 and SK-MEL-28 cells.
| M.Wt | 1104.127 | |
| Formula | C52H69F3IN7O6S | |
| Appearance | Solid | |
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1. Jianping Hu, et al. J Med Chem. 2020 Dec 24;63(24):15883-15905.
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