| Cat. No. |
Product Name |
Information |
| PC-26369 |
HD-TAC7
HDAC3 PROTAC
|
HD-TAC7 is a potent, selective Cereblon-dependent HDAC3 PROTAC degrader with DC50 of 0.32 uM in RAW 264.7 cells. |
| PC-26132 |
dGPX4
GPX4 PROTAC
|
dGPX4 is a potent GPX4 PROTAC degrader, depletes GPX4 via proteasomal protein degradation, induces cell-selective ferroptosis by targeting cancer cell microenvironment. |
| PC-25906 |
G6374
IRE1 PROTAC
|
G6374 is a selective, effective PROTAC degrader for endogenous IRE1 with DC50 of 0.04 uM and Dmax of 93% in AMO1 multiple myeloma (MM) cells. |
| PC-25679 |
G-6599
SMARCA2/A4 degrader
|
G-6599 is a potent, specific small-molecule SMARCA2/A4 PROTAC degrader with DC50 of 17 pM and 57 pM respectively (SW1573 cells, 20 h, Dmax=95%), acting via the recruitment of FBXO22. |
| PC-25674 |
AMPTX1
BRD9 degrader
|
AMPTX-1 is a potent, selective and reversibly covalent BRD9 degrader with DC50 of 0.5 nM and Dmax =93% (MV4-11 cell, 6h). |
| PC-25670 |
Golcadomide
IKZF1/3 degrader
|
Golcadomide (CC-99282) is a potent, oral cereblon-modulating CELMoD agent that acts as cereblon-based molecular glue degrader of both IKZF1 and IKZF3. |
| PC-25655 |
EPIC-0726
PTRF PROTAC
|
EPIC-0726 is a selective PROTAC degrader of polymerase I and transcript release factor (PTRF/Cavin1) with DC50 of 5.12 uM in U87-MG cells, Dmax=90.07%. |
| PC-25623 |
MA203
CHK1 PROTAC
|
MA203 is a potent, selective Checkpoint kinase-1 (CHK1) PROTAC degarder with DC50 of 5 uM in MIA PaCa-2 (24 h). |
| PC-25493 |
FTO degrader FP54
FTO PROTAC
|
FTO degrader FP54 is a selective PROTAC degrader of fat mass and obesity-associated protein (FTO) with DCof 0.68 μM in NB4 cells and 0.71 μM in MOLM-13 cells, Dmax>95%. |
| PC-25407 |
ASP3082
KRAS G12D PROTAC
|
Setidegrasib (ASP3082) is a potent, selective KRAS G12D PROTAC degrader with DC50 of 38 nM, effectively induces KRAS(G12D) protein degradation with remarkable selectivity. |
| PC-25334 |
ABS-752
GSPT1/NEK7 degrader
|
ABS-752 is a prodrug of ABT-002 that could be activated by the monoamine oxidase VAP-1, ABS-752 is a molecular glue degrader of GSPT1 and NEK7 with DC50 of 1 nM and 9 nM in Hep3B cells (24 h, Dmax>95%). |
| PC-25288 |
UNC6587
TBK1 PROTAC
|
UNC6587 is a selective cereblon-based TBK1 proteolysis targeting chimera (PROTAC) degrader, efficiently eliminates TBK1 protein levels in ccRCC cells, while not affecting its close family member IKKε. |
