| Cat. No. |
Product Name |
Information |
| PC-25679 |
G-6599
SMARCA2/A4 degrader
|
G-6599 is a potent, specific small-molecule SMARCA2/A4 PROTAC degrader with DC50 of 17 pM and 57 pM respectively (SW1573 cells, 20 h, Dmax=95%), acting via the recruitment of FBXO22. |
| PC-25674 |
AMPTX1
BRD9 degrader
|
AMPTX-1 is a potent, selective and reversibly covalent BRD9 degrader with DC50 of 0.5 nM and Dmax =93% (MV4-11 cell, 6h). |
| PC-25670 |
Golcadomide
IKZF1/3 degrader
|
Golcadomide (CC-99282) is a potent, oral cereblon-modulating CELMoD agent that acts as cereblon-based molecular glue degrader of both IKZF1 and IKZF3. |
| PC-25655 |
EPIC-0726
PTRF PROTAC
|
EPIC-0726 is a selective PROTAC degrader of polymerase I and transcript release factor (PTRF/Cavin1) with DC50 of 5.12 uM in U87-MG cells, Dmax=90.07%. |
| PC-25623 |
MA203
CHK1 PROTAC
|
MA203 is a potent, selective Checkpoint kinase-1 (CHK1) PROTAC degarder with DC50 of 5 uM in MIA PaCa-2 (24 h). |
| PC-25407 |
ASP3082
KRAS G12D PROTAC
|
Setidegrasib (ASP3082) is a potent, selective KRAS G12D PROTAC degrader with DC50 of 38 nM, effectively induces KRAS(G12D) protein degradation with remarkable selectivity. |
| PC-25334 |
ABS-752
GSPT1/NEK7 degrader
|
ABS-752 is a prodrug of ABT-002 that could be activated by the monoamine oxidase VAP-1, ABS-752 is a molecular glue degrader of GSPT1 and NEK7 with DC50 of 1 nM and 9 nM in Hep3B cells (24 h, Dmax>95%). |
| PC-25288 |
UNC6587
TBK1 PROTAC
|
UNC6587 is a selective cereblon-based TBK1 proteolysis targeting chimera (PROTAC) degrader, efficiently eliminates TBK1 protein levels in ccRCC cells, while not affecting its close family member IKKε. |
| PC-24854 |
YTHu78
KDM5B PROTAC
|
YTHu78 is a potent, selective CRBN ligand-based KDM5B PROTAC degrader, effectively induce KDM5B degradation in MV-4-11 and MM.1S cell lines, exhibits comparable degradation efficacy toward KDM5B and KDM5A. |
| PC-24632 |
MS9117
LSD1 PROTAC
|
MS9117 is a potent, selective CRBN-based LSD1 PROTAC degrader, effectively degrades LSD1 and demonstrates superior antiproliferative effects in AML cells. |
| PC-24472 |
KTX207
PDE4 PROTAC
|
KTX207 is a potent, selective BI 1015550-based PDE4 PROTAC degrader, degrades PDE4D and PDE4B shortforms in A549 cells with IC50 of 10 pM and 400 pM, respectively. |
| PC-24380 |
CDK2 degrader Cpd 1
CDK2 degrader
|
CDK2 degrader Cpd 1 is a potent, selective heterobifunctional CDK2 degrader with DC50 of <10 nM and Dmax>90% in TOV21G cells, 1,000-fold selectivity versus CDK1. |
