| Cat. No. |
Product Name |
Information |
| PC-25334 |
ABS-752
GSPT1/NEK7 degrader
|
ABS-752 is a prodrug of ABT-002 that could be activated by the monoamine oxidase VAP-1, ABS-752 is a molecular glue degrader of GSPT1 and NEK7 with DC50 of 1 nM and 9 nM in Hep3B cells (24 h, Dmax>95%). |
| PC-25288 |
UNC6587
TBK1 PROTAC
|
UNC6587 is a selective cereblon-based TBK1 proteolysis targeting chimera (PROTAC) degrader, efficiently eliminates TBK1 protein levels in ccRCC cells, while not affecting its close family member IKKε. |
| PC-24854 |
YTHu78
KDM5B PROTAC
|
YTHu78 is a potent, selective CRBN ligand-based KDM5B PROTAC degrader, effectively induce KDM5B degradation in MV-4-11 and MM.1S cell lines, exhibits comparable degradation efficacy toward KDM5B and KDM5A. |
| PC-24632 |
MS9117
LSD1 PROTAC
|
MS9117 is a potent, selective CRBN-based LSD1 PROTAC degrader, effectively degrades LSD1 and demonstrates superior antiproliferative effects in AML cells. |
| PC-24472 |
KTX207
PDE4 PROTAC
|
KTX207 is a potent, selective BI 1015550-based PDE4 PROTAC degrader, degrades PDE4D and PDE4B shortforms in A549 cells with IC50 of 10 pM and 400 pM, respectively. |
| PC-24380 |
CDK2 degrader Cpd 1
CDK2 degrader
|
CDK2 degrader Cpd 1 is a potent, selective heterobifunctional CDK2 degrader with DC50 of <10 nM and Dmax>90% in TOV21G cells, 1,000-fold selectivity versus CDK1. |
| PC-24182 |
KT-253
MDM2 degrader
|
Seldegamadlin (KT-253, KT253) is a potent, selective heterobifunctional MDM2 degrader (DC50=0.4 nM) and p53 stabilizer. |
| PC-24090 |
cGAS PROTAC TH35
cGAS degrader
|
cGAS PROTAC TH35 is an effective, selective CRBN-recruiting cGAS-targeting PROTAC degrader with DC50 of 0.9 uM and 4.6 uM in THP-1 and RAW 264.7 cells respectively, Dmax >90% at 20 uM. |
| PC-24058 |
RDN8011
KDM4 PROTAC
|
RDN8011 is a potent, selective first-in-class PROTAC degrader of KDM4 with DC50 of 37-50 nM for KDM4A/KDM4B/KDM4C in in KYSE-150 cells, while sparing KDM4D. |
| PC-23963 |
DEG-77
IKZF2/CK1α degarder
|
DEG-77 is a more soluble analog of DEG-35, dual degrader of IKZF2 and casein kinase 1α (CK1α) with DC50 of 15.3 nM and 10 nM respectively. |
| PC-23962 |
CC-91633
CK1α degrader
|
CC-91633 (BMS-986397) is a first-in-class, potent and selective CRBN-based molecular glue degrader of casein Kinase 1α (CK1α). |
| PC-23961 |
DEG-35
IKZF2/CK1α degarder
|
DEG-35 is a potent, cereblon-dependent, dual degrader of IKZF2 ((DC50=4.4 nM, DCmax=92%)) and casein kinase 1α (CK1α, DC50=1.4 nM, DCmax=84%), shows leukemic cell killing activity. |
