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DOT1L808

Chemical Structure : DOT1L808

CAS No.: 3124614-35-0

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DOT1L808

Catalog No.: PC-27629Not For Human Use, Lab Use Only.

DOT1L808 is potent and highly selective DOT1L PROTAC degrader with DC50 of 5 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

DOT1L808 is potent and highly selective DOT1L PROTAC degrader with DC50 of 5 nM.
DOT1L808 exhibits cell viability inhibition, which is highly dependent on the MLL-r status of leukemia cell lines, and retains activity against menin inhibitor-resistant cells.
DOT1L808 achieves complete tumor regression in an orthotopic leukemia model without overt toxicity.

Physicochemical Properties

M.Wt 1301.90
Formula C61H72ClF3N14O9S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

References

1. Quan S, et al. J Med Chem. 2026 Feb 26;69(4):4439-4468.

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