Chemical Structure : DK-5070
CAS No.:
DK-5070
(DK5070)
Catalog No.: PC-27736Not For Human Use, Lab Use Only.
DK-5070 is a potent, selective UHRF1-recruiting degrader of GPX4 with DC50 of 17.4 nM, Dmax of 84% in in HT1080 cells (24 h).
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
DK-5070 is a potent, selective UHRF1-recruiting degrader of GPX4 with DC50 of 17.4 nM, Dmax of 84% in in HT1080 cells (24 h).
DK-5070 induced pronounced GPX4 degradation following 24 h treatment at 50 nM.
DK-5070 (20 nM) achieved greater GPX4 degradation than dGPX4 at 200 nM.
DK-5070 exhibits antiproliferative activity against with IC50 of 47 nM in HT1080 cells.
DK-5070 induces rapid and durable GPX4 degradation via the ubiquitin-proteasome system.
DK-5070 covalently recruits UHRF1 to mediate the degradation of GPX4 via the proteasome pathway, enhances the GPX4-UHRF1 interaction with Kd of 1.02 uM.
DK-5070 suppresses cell proliferation primarily through GPX4 degradation-induced ferroptosis.
DK-5070 (10-30 mg/kg) significantly suppressed tumor growth in a dose-dependent manner in HT1080 xenograft mouse models.
Physicochemical Properties
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M.Wt
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532.44
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Formula
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C24H23Cl2N5O3S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-(4-(2-azidoethoxy)-3-chlorophenyl)-2-chloro-N-(2-oxo-2-(phenethylamino)-1-(thiophen-2-yl)ethyl)acetamide
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References
1. Lin Z, et al. Adv Sci (Weinh). 2026 Aug 19:e77201.
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