| Cat. No. |
Product Name |
Information |
| PC-22120 |
ARV-393
BCL6 PROTAC
|
ARV-393 (Zaloblideg, ARV393) is a potent, orally bioavailable BCL6 targeting PROTAC degrader with DC50 and GI50 values <1 nM in numerous DLBCL and BL cell lines. |
| PC-22117 |
BMS-986365
AR degrader
|
BMS-986365 (CC-94676) is a highly potent and selective androgen receptor (AR) degrader with DC50 of 10-40 nM, induces rapid and deep degradation of both wildtype and mutant forms of AR. |
| PC-22075 |
P1D-34
Pin1 degrader
|
P1D-34 is a first-in-class, potent and covalent PROTAC degrader of Pin1 with DC50 value of 177 nM in MV-4-11 cells, Dmax of 95%. |
| PC-22055 |
AU-24118
mSWI/SNF ATPase PROTAC
|
AU-24118 is a potent, selective, and orally bioavailable degrader of mSWI/SNF ATPases (SMARCA2, SMARCA4) and PBRM1. |
| PC-21992 |
LC-1-40
NUDT1 PROTAC
|
LC-1-40 is a potent, specific NUDT1 (MTH1) degrader/PROTAC with DC50 of 0.97 nM in SHEP MYCN-ER cells, Dmax value of 96% at 50 nM. |
| PC-21928 |
Dual BCL-xL, BCL-2 degrader 753b
BCL-xL/BCL-2 PROTAC
|
Dual BCL-xL/BCL-2 degrader 753b (Compound 753b) is a highly potent dual BCL-xL and BCL-2 PROTAC degrader with DC50 of 6 nM and 48 nM for degrading BCL-xL and BCL-2 in 293T cells respectively. |
| PC-21676 |
WD6305
METTL3-METTL14 PROTAC
|
WD6305 is a potent and selective proteolysis-targeting chimera (PROTAC) degrader of METTL3-METTL14 complex with DC50 of 140 nM (METTL3), Dmax of 91.9% in Mono-Mac-6 AML cell line. |
| PC-21662 |
ACBI3
pan-KRAS PROTAC
|
ACBI3 is a selective, potent and in vivo active pan-KRAS PROTAC degrader, potently degrades 13 out of 17 of the most prevalent oncogenic KRAS alleles (DC50=3.9 nM in GP2d cells). |
| PC-21653 |
DAS-CHO-5-oCRBN
c-Src PROTAC
|
DAS-CHO-5-oCRBN is a potent and selective PROTAC for c-Src kinase with DC50 value of 55 nM in CAL148 cells. |
| PC-21642 |
DBr-1
DCAF1-BRD9 PROTAC
|
DBr-1 (DCAF1-BRD9 PROTAC) is a potent, selective DCAF1-BRD9 PROTAC (DC50=90 nM, HEK293) by coupling the BRD9 bromodomain binder BI-9564 via a piperidine and aliphatic carbon linker to the piperazine of DCAF1 binder. |
| PC-21567 |
BGB-16673
BTK PROTAC
|
Catadegbrutinib (BGB-16673) is an orally available heterobifunctional BTK PROTAC degrader that binds to BTK and E3 ligase, degrades wildtype BTK and multiple mutant forms via ubiquitination. |
| PC-21533 |
KH-103
GR PROTAC
|
KH-103 is a highly potent, catalytically-driven glucocorticoid receptor (GR) PROTAC degrader, demonstrate excellent performance in passively preventing ligand-induced gene expression activation in the absence of partial agonistic transcriptional triggering and crosstalk inhibition. |
