| Cat. No. |
Product Name |
Information |
| PC-23155 |
ZLC491
CDK12/13 PROTAC
|
ZLC491 is a potent, selective, and orally bioavailable CDK12/13 PROTAC degrader with DC50 values of 32 and 28 nM, respectively, in TNBC MDA-MB-231 cells. |
| PC-23149 |
YJ1206
CDK12/13 PROTAC
|
YJ1206 is a selective, orally bioavailable CDK12/13 PROTAC degrader, shows potent degradation effects and inhibits VCaP cell viability (IC50=12.5 nM). |
| PC-23133 |
SMARCA2 PROTAC YD23
SMARCA2 PROTAC
|
SMARCA2 PROTAC YD23 is a potent and selective proteolysis targeting chimera (PROTAC) targeting SMARCA2 with DC50 of 64 nM in H1792 cells and Dmax of 88%. |
| PC-23063 |
BTX-1188
GSPT1 and IKZF1/3 PROTAC
|
Sontigidomide (BTX-1188) is a first-in-class dual degrader of GSPT1 and IKZF1/3 with DC50 of 0.2 nM, 1 nM and 1 nM for GSPT1, IKZF1 and IKZF3 respectively, in DOHH-2 (lymphoma) cells. |
| PC-22955 |
MS8588
cGAS DUBTAC
|
MS8588 is a first-in-class DUBTAC of cGAS, a key component of the cGAS-STING pathway, stabilizes cGAS and increases the cGAS downstream effector protein STING. |
| PC-22954 |
MS7829
cGAS DUBTAC
|
MS7829 is a first-in-class DUBTAC of cGAS, a key component of the cGAS-STING pathway, stabilizes cGAS and increases the cGAS downstream effector protein STING. |
| PC-22939 |
CW-3308
BRD9 PROTAC
|
CW-3308 is a potent, selective, and orally bioavailable BRD9 PROTAC degrader, effectively reduces the BRD9 protein by 68% at 1 nM (DC50 < 1 nM) and 90% at 10 nM in the G401 rhabdoid tumor cell line. |
| PC-22897 |
HPK1 PROTAC C3
HPK1 PROTAC
|
HPK1 PROTAC C3 is a potent, selective and orally active HPK1 PROTAC degrader with DC50 of 21.26 nM, Dmax of 80.50% in Jurkat cells. |
| PC-22832 |
NCOA4 PROTAC V3
NCOA4 PROTAC
|
NCOA4 PROTAC V3 is a highly efficient VHL-based nuclear receptor coactivator 4 (NCOA4) PROTAC degrader (DC50=3 nM, HeLa cells) and potent ferroptosis inhibitor. |
| PC-22767 |
KT-413
IRAK4 PROTAC
|
Zomiradomide (KT-413) is a potent PROTAC degrader of IRAK4 and IMiD substrates, induces the potent degradation of IRAK4, Ikaros, and Aiolos with DC50 of 6 nM, 1 nM and 1 nM, respectively in OCI-Ly10 cells. |
| PC-22750 |
BSJ-5-63
CDK12/7/9 PROTAC
|
BSJ-5-63 is a potent, triple PROTAC degrader targeting cyclin-dependent kinases (CDKs) CDK12, CDK7, and CDK9, downregulates HRR genes and inhibits AR signaling. |
| PC-22748 |
G9a degrader G9D-4
G9a PROTAC
|
G9D-4 is a first-in-class, potent, selective PRTOAC degrader of protein lysine methyltransferase G9a (EHMT2, KMT1C) with DC50 of 0.1 uM in PANC-1 cells, highly selective over GLP (DC50>10 uM). |
