| Cat. No. |
Product Name |
Information |
| PC-20560 |
NX-2127
BTK PROTAC
|
NX-2127 (NX2127) is a hetero-bifunctional, orally active PROTAC that induces the degradation of BTK and IKZF3 ubiquitination and proteasomal degradation in cells through recruitment of cereblon (CRBN). |
| PC-20466 |
BSJ-05-037
ITK PROTAC
|
BSJ-05-037 is a potent and selective heterobifunctional degrader of ITK with DC50 of 17.6-41.8 nM in TCL lines DERL-2 and Hut78. |
| PC-20464 |
BI 1810284
SMARCA2 PROTAC
|
BI 1810284 (ACBI2, BI 01810284) is a potent, selective and orally bioavailable VHL-recruiting PROTAC degrader of SMARCA2 (DC50=1 nM in RKO cells), 30-fold selectivity over SMARCA4. |
| PC-20356 |
UNC8153
NSD2 PROTAC
|
UNC8153 (UNC 8153) is a selective NSD2-targeted degrader with binding Kd of 24 nM for NSD2, potently and selectively reduces cellular levels of both NSD2 protein (DC50=350 nM) and H3K36me2 chromatin mark. |
| PC-20349 |
DU-14
PTP1B/TC-PTP PROTAC
|
DU-14 is a highly potent and selective small molecule degrader for both PTP1B and TC-PTP with DC50 values of 4.3 and 4.8 nM, respectively, in HEK293 cells after 16 hours treatment. |
| PC-20323 |
LL-K8-22
CDK8 degarder
|
LL-K8-22 is a potent, selective dual degrader of of CDK8 and cyclin C (MDA-MB-468 cell DC50, 2.52 and 2.64 uM), significantly degrades CDK8 without reducing CDK19 and does not degrade other cyclin proteins. |
| PC-20168 |
ZZ151
SOS1 PROTAC
|
ZZ151 (ZZ-151) is a highly potent and selective SOS1 degrader PROTAC with DC50 of 15.7 nM (Dmax=100%). |
| PC-20167 |
TMX-4153
PIP4K2C PROTAC
|
TMX-4153 (TMX4153) is a bivalent PIP4K2C degrader (MOLT4 cells, DC50=24 nM, Dmax=921% at 1 uM) based on TMX-4084, rapidly and selectively degrades endogenous PIP4K2C. |
| PC-20153 |
TMX-4100
PDE6D PROTAC
|
TMX-4100 (TMX4100) is a highly potent PDE6D degrader with DC50 of <200 nM in MOLT4 cells, does not degrade CK1α and IKZF1/IKZF3. |
| PC-20152 |
TMX-4113
PDE6D PROTAC
|
TMX-4113 (TMX4113) is a highly potent PDE6D degrader with DC50 of 40 nM in MM.1S cells, does not degrade CK1α, IKZF1/IKZF3. |
| PC-20151 |
TMX-4116
CK1α PROTAC
|
TMX-4116 (TMX4116) is a highly potent casein kinase 1α (CK1α) degrader with DC50 of <200 nM (CK1α) in MOLT4 cells, does not degrade PDE6D and IKZF1/IKZF3. |
| PC-20149 |
FPFT-2216
KZF1 and CK-1α degrader
|
FPFT-2216 (FPFT2216) is a thalidomide derivative cereblon modulator that shows an inhibitory effect toward IKZF1 protein level, upregulates the production of IL-2 and degrades IKZF1 as well as CK-1α among ubiquitin–proteasomal degradative substrates of IMiDs. |
