| Cat. No. |
Product Name |
Information |
| PC-49057 |
CDK2 degrader CPS2
CDK2 degrader
|
CDK2 degrader CPS2 is a potent, selective CDK2 degarder (PROTAC) with IC50 of 24 nM, potently and specifically induces CDK2 degradation in various cancer cell lines (MDA-MB-231, DC50=8 nM; MV-4-11, DC50=1 nM). |
| PC-49045 |
MD-224
MDM2 PROTAC
|
MD-224 is a small-molecule MDM2 degrader based on the proteolysis targeting chimera (PROTAC), effectively induces rapid degradation of MDM2 at concentrations <1 nM in human leukemia cells. |
| PC-49044 |
ARD-69
AR degarder
|
ARD-69 is a highly potent PROTAC degrader of androgen receptor (AR), effectively induces degradation of AR protein in AR-positive prostate cancer cell lines LNCaP, VCaP, and 22Rv1 with DC50 values of 0.86, 0.76, and 10.4 nM, respectively. |
| PC-47084 |
JCS-1
DcpS PROTAC
|
JCS-1 is a RG3039-based degarder (PROTAC) of the RNA decapping scavenger protein DcpS exhibiting effective degradation of DcpS at nanomolar concentrations, non-covalently binds DcpS and recruits the E3 ligase VHL, induces potent, rapid, and sustained DcpS degradation in AML cell lines. |
| PC-47018 |
ZXH-1-161
GSPT1 degrader
|
ZXH-1-161 is a potent, selective small-molecule GSPT1 degrader, inhibits ceell viability in MM1.S with IC50 of 39 nM. |
| PC-47017 |
SJ6986
GSPT1/2 degrader
|
SJ6986 is a potent, selective, and orally bioavailable small-molecule GSPT1/2 degrader with DC50 of 2.1 nM (GSPT1), demonstrates antiproliferative activities in leukemia cell lines MV4-11 and MHH-CALL-4 with EC50 of 1.5 and 0.4 nM, respectively. |
| PC-73321 |
CFT7455
IKZF1/3 degrader
|
Cemsidomide (CFT7455) is a highly potent and selective degarder of IKZF1/3 with cereblon binding IC50 of 0.4 nM and picomolar DC50. |
| PC-73316 |
CFT8634
BRD9 BiDAC degrader
|
CFT-8634 (CFT8634) is a potent, selective, orally bioavailable BRD9 BiDAC degrader with DC50 of 3 nM, high selectivity over BRD4 abd BRD7. |
| PC-73296 |
QC-01-175
Tau PROTAC
|
QC-01-175 is a hetero-bifunctional molecule designed to engage both tau and Cereblon (CRBN) to trigger tau ubiquitination and proteasomal degradation (tau PROTAC). |
| PC-73287 |
HDAC8 PROTAC 1
HDAC8 degrader
|
HDAC8 PROTAC 1 is a first-in-class proteolysis targeting chimera (PROTAC) for selective degradation of histone deacetylase 8 (HDAC8). |
| PC-73152 |
ACBI1
SMARCA2/4 PROTAC
|
ACBI1 is a potent and cooperative degrader (PROTAC) of BAF ATPase subunits SMARCA2, SMARCA4 and PBRM1 with DC50 of 6 nM, 11 nM and 32 nM, respectively. |
| PC-72930 |
YTK-105 linker conjugate 1
AUTOTAC conjugate
|
YTK-105 linker conjuate 1 is a PEG linker added to p62-ZZ ligand YTK-105 for AUTOTAC design. |
