| Cat. No. |
Product Name |
Information |
| PC-24640 |
HDAC7 PROTAC B14
HDAC7 degrader
|
HDAC7 PROTAC B14 is a potent, exceedingly selective HDAC7 PROTAC degrader with DC50 of 25.1 nM in NB4 cells. |
| PC-24632 |
MS9117
LSD1 PROTAC
|
MS9117 is a potent, selective CRBN-based LSD1 PROTAC degrader (DC50<40 nM in THP-1 cells), effectively degrades LSD1 in a concentration-, time-, and proteasome-dependent manner. |
| PC-24555 |
PLX-4545
IKZF2 degrader
|
PLX-4545 (PLX4545) is a potent and selective, orally bioavailable IKZF2 degrader, that depletes IKZF2 and converts suppressive Tregs into effector-like T-cells leading to antitumor immunity. |
| PC-24554 |
PVTX-405
IKZF2 degrader
|
PVTX-405 is a potent, highly selective, rapid and orally efficacious CRBN-dependent glue degrader of IKZF2 with DC50 of 0.7 nM in IKZF2 HiBiT degradation assay in HEK293 cells, Dmax = 91%. |
| PC-24551 |
BD-9136
BRD4 degrader
|
BD-9136 is a potent, highly selective PROTAC degrader of BRD4 with DC50 of 1.2 nM (MV-4-11 cell, 4 h), Dmax=99%, displays >1000-fold selective over BRD2 and BRD3 proteins. |
| PC-24472 |
KTX207
PDE4 PROTAC
|
KTX207 is a potent, selective BI 1015550-based PDE4 PROTAC degrader, degrades PDE4D and PDE4B shortforms in A549 cells with IC50 of 10 pM and 400 pM, respectively. |
| PC-24380 |
CDK2 degrader Cpd 1
CDK2 degrader
|
CDK2 degrader Cpd 1 is a potent, selective heterobifunctional CDK2 degrader with DC50 of <10 nM and Dmax>90% in TOV21G cells, 1,000-fold selectivity versus CDK1. |
| PC-24182 |
KT-253
MDM2 degrader
|
Seldegamadlin (KT-253, KT253) is a potent, selective heterobifunctional MDM2 degrader (DC50=0.4 nM) and p53 stabilizer. |
| PC-24133 |
Epaldeudomide
IKZF1/3 molecular glue
|
Epaldeudomide (KPG-818) is a molecular glue modulator of the E3 ubiquitin ligase complex CRL4-CRBN, shows high cereblon (CRBN) binding affinity and potent degradation of Aiolos (IKZF3) and Ikaros (IKZF1), possesses remarkable broad-spectrum immunomodulatory effects, anti-angiogenic, and anti-tumor effects. |
| PC-24090 |
cGAS PROTAC TH35
cGAS degrader
|
cGAS PROTAC TH35 is an effective, selective CRBN-recruiting cGAS-targeting PROTAC degrader with DC50 of 0.9 uM and 4.6 uM in THP-1 and RAW 264.7 cells respectively, Dmax >90% at 20 uM. |
| PC-24058 |
RDN8011
KDM4 PROTAC
|
RDN8011 is a potent, selective first-in-class PROTAC degrader of KDM4 with DC50 of 37-50 nM for KDM4A/KDM4B/KDM4C in in KYSE-150 cells, while sparing KDM4D. |
| PC-24047 |
KT-333
STAT3 PROTAC
|
KT-333 (KT333) is a potent, highly specific potent heterobifunctional PROTAC degrader of STAT3 with DC50 of 2.5 -11.8 nM in anaplastic T cell lymphoma (ALCL) lines. |
