Catalog No.: PC-23674Not For Human Use, Lab Use Only.
SMD-3236 is a highly potent, exceptionally selective SMARCA2 PROTAC degrader with DC50 of 0.5 nM and Dmax = 96% in H838 NSCLC cells, >2000-fold selectivity over SMARC4.
SMD-3236 is a highly potent, exceptionally selective SMARCA2 PROTAC degrader with DC50 of 0.5 nM and Dmax = 96% in H838 NSCLC cells, >2000-fold selectivity over SMARC4.
SMD-3236 binds to SMARCA2 and SMARCA4 with IC50 values of 42.2 and 60.0 nM, respectively, in TR-FRET binding assays.
SMD-3236 demonstrates GI50 values ranging from 1.5 to 9.8 nM and Imax values spanning 71–95% against 5 SMARCA4-deficient cancer cell lines, demonstrates >1000-fold selectivity over cancer cell lines carrying wild-type SMARCA4.
SMD-3236 (10 mg/kg via the tail vein injection) induce SMARCA2 degradation in the H838 SMARCA4-deficient xenograft tumor model in mice.
SMD-3236 (10 and 30 mg/kg intravenously for 3 weeks) effectively inhibits tumor growth in the H838 xenograft tumor model in SCID mice.
