| Cat. No. |
Product Name |
Information |
| PC-24991 |
MI1013
PXR PROTAC
|
MI1013 is a potent, selective CRBN-base PROTAC degrader of pregnane X receptor (PXR) designed by connecting SPA70 and pomalidomide with PEG linker, has DC50 of 89 nM and Dmax of 82% in HepaRG cells. |
| PC-24975 |
SD-91
STAT3 PROTAC
|
SD-91 is a potent, selective STAT3 PROTAC degrader with DC50 of 17 nM in SU-DHL-1 cell line. |
| PC-24938 |
NK7-902
NEK7 degrader
|
NK7-902 is a potent and selective cereblon (CRBN) glue degrader of NEK7 with DC50 of 0.2 nM in human primary monocytes (Dmax>95%). |
| PC-24930 |
YT-58
BTK PROTAC
|
YT-58 is a selective, RBBP7-recruiting BTK PROTAC degrader with DC50 of 0.17 uM (Dmax=83%), induces BTK degradation via the proteasome pathway and effectively inhibits BTK and PLCγ2 phosphorylation. |
| PC-24916 |
PRMT4 PROTAC C199
PRMT4 degrader
|
PRMT4 PROTAC C199 is a potent, selective PROTAC degrader targeting PRMT4 with DC50 of 106 nM and Dmax=93.1% in NCI-H929 cells, showes high selectivity for PRMT4 over other PRMTs. |
| PC-24903 |
SJ46420
BRD3 PROTAC
|
SJ46420 is the a methyl-ester prodrug of SJ46421 and specific JQ1-based KLHDC2 PROTAC protein degrader of BRD3, induces selective BRD3 degradation in PC3 cells with DC50 of 487 nM (Dmax=99%). |
| PC-24902 |
SJ46421
BRD3 PROTAC
|
SJ46421 is a specific JQ1-based KLHDC2 PROTAC protein degrader of BRD3, induces selective BRD3 degradation in cells, promotes selective cooperative ternary complex formation with BRD3BD2 with IC50 of 7.8 nM. |
| PC-24888 |
INY-05-040
AKT PROTAC
|
INY-05-040 is a second-generation pan-AKT PROTAC degrader, selectively and rapidly (<5 h) degrades all three AKT isoforms and inhibits downstream signaling and cell proliferation in 288 cancer cell lines. |
| PC-24880 |
dASK1-VHL
ASK1 PROTAC
|
dASK1-VHL is a potent, selective cereblon (CRBN)-based PROTAC degrader of apoptosis signal-regulating kinase 1 (ASK1). |
| PC-24854 |
YTHu78
KDM5B PROTAC
|
YTHu78 is a potent, selective CRBN ligand-based KDM5B PROTAC degrader, effectively induce KDM5B degradation in MV-4-11 and MM.1S cell lines, exhibits comparable degradation efficacy toward KDM5B and KDM5A. |
| PC-24813 |
CDK9 degrader AZ-9
CDK9 degrader
|
CDK9 degrader AZ-9 is a potent, ATG101-recruiting selective CDK9 degrader, significantly degrades CDK9 and Cyclin T1 with DC50 of 0.4073 and 1.215 uM in HCT116 cells. |
| PC-24804 |
WZH-17-002
ALK PROTAC
|
WZH-17-002 is a potent, selective ALK PROTAC degrader with DC50 of 25 nM both in H3122 and DFCI076 cells. |
