| Cat. No. |
Product Name |
Information |
| PC-22852 |
MGP-39
MELK PROTAC
|
MGP-39 is a first-in-class PROTAC degrader targeting maternal embryonic leucine zipper kinase (MELK), induced potent and rapid degradation of MELK in Burkitt lymphoma cell (Dmax=91.6%), and IC50 of 1.8 uM for RAMOS cell line. |
| PC-22824 |
AZ3137
AR degrader
|
AZ3137 (AZ′3137) a potent, selective, orally bioavailable androgen aeceptor (AR) PROTAC degrader with DC50 of 22 nM and 92 nM for LNCaP cells expressing WT AR and AR T878A/L702H respectively. |
| PC-22823 |
MMH2
BRD4 degrader
|
MMH2 is a potent, selective, covalent JQ1-derived PROTAC degrader of BRD4 via DCAF16 (BRD4BD2, DC50=1 nM, Dmax=95%), functions as a molecular glue to recruit DCAF16 selectively to BRD4 BD2, causing degradation of BRD4. |
| PC-22822 |
MMH1
BRD4 degrader
|
MMH1 is a potent, selective, covalent JQ1-derived PROTAC degrader of BRD4 via DCAF16 (BRD4BD2, DC50=1 nM), functions as a molecular glue to recruit DCAF16 selectively to BRD4 BD2, causing degradation of BRD4. |
| PC-22821 |
TMX1
BRD4 degrader
|
TMX1 is a potent, selective, covalent JQ1-derived PROTAC degrader of BRD4 via DCAF16, functions as a molecular glue to recruit DCAF16 selectively to BRD4 BD2, causing degradation of BRD4. |
| PC-22820 |
KLHDC2-AR PROTAC K2-AR-1
AR PROTAC
|
KLHDC2-AR PROTAC K2-AR-1 is a hihgly potent KLHDC2-directed PROTAC degrader of androgen receptor (AR), wihch is dependent on the UPS and KLHDC2. |
| PC-22819 |
KLHDC2-BRD4 PROTAC K2-B4-5e
BRD4 PROTAC
|
KLHDC2-BRD4 PROTAC K2-B4-5e is a hihgly potent KLHDC2-directed PROTAC degrader of BRD4 with DC50 of 6.2 nM against HiBiT-BRD4, Dmax=93%, in PC-3 cells. |
| PC-22803 |
HDAC8 PROTAC Z16
HDAC8 PROTAC
|
HDAC8 PROTAC Z16 (CZH-726) is a potent, selective HDAC8 PROTAC degrader with DC50 of 0.32 nM, Dmax=97% in Jurkat cells. |
| PC-22785 |
XM-U-14
USP7 PROTAC
|
XM-U-14 is a highly potent, selective and efficacious USP7 PROTAC degrader with DC50 of 0.7 nM in RS4;11 cell, Dmax of 93.1%. |
| PC-22771 |
SIAIS630121
NAMPT PROTAC
|
SIAIS630121 is a highly selective NAMPT-targeted PROTAC that promote rapid and potent degradation of iNAMPT and eNAMPT in a cereblon-dependent manner. |
| PC-22770 |
SIAIS630120
NAMPT PROTAC
|
SIAIS630120 is a highly selective NAMPT-targeted PROTAC that promote rapid and potent degradation of iNAMPT and eNAMPT in a cereblon-dependent manner. |
| PC-22769 |
NAMPT PROTAC 632005
NAMPT PROTAC
|
NAMPT PROTAC 632005 is a potent, selective, next-generation PROTAC degrader of nicotinamide phosphoribosyltransferase (NAMPT) with DC50 of < 1 nM and Dmax of 98.2% in Jurkat cells, simultaneously degrades iNAMPT and eNAMPT. |
