| Cat. No. |
Product Name |
Information |
| PC-24376 |
MS115
PRMT5 PROTAC
|
MS115 is a potent, selective best-in-class PRMT5 PROTAC degrader, induces rapid and robust degradation of PRMT5 (DC50=17.4 nM) and its binding partner MEP50 (DC50=11.3 nM, MDAMB468 cells), in a time-, concentration-, VHL- and UPS-dependent manner. |
| PC-24355 |
MS2133
DOT1L PROTAC
|
MS2133 is a first-in-class, potent and selective DOT1L PROTAC degrader with a DC50 of 56 nM and Dmax of 69 in THP-1 cells and a DC50 of 25 nM and Dmax of 93 in MV4-11 cells. |
| PC-24279 |
YX0597
CDK9 PROTAC
|
YX0597 is a potent, selective CDK9 PROTAC degrader, potently inhibits GEAC cell growth, especially in radiation-resistant tumor cells. |
| PC-24278 |
TO-1187
HDAC6 PROTAC
|
TO-1187 is a potent, selective, cereblon (CRBN)-based HDAC6 PROTAC degrader with DC50 of 5.81 nM in MM.1S cells (6 h), Dmax of 94%. |
| PC-24265 |
HDAC6 PROTAC 17c
HDAC6 PROTAC
|
HDAC6 PROTAC 17c is a potent, selective CRBN- and VHL-recruiting PROTAC degrader of HDAC6 with DC50 of 14 nM in MM.1S cells, Dmax of 91%, high selective over other HDACs. |
| PC-24242 |
BT-O2C
p300 PROTAC
|
BT-O2C is a potent, selective PROTAC degrader of p300, potently degrades p300 while sparing CBP, is cytotoxic in CIC::DUX4 sarcoma (CDS) cell lines (IC50=152-221 nM). |
| PC-24233 |
PP-C8
CDK12 PROTAC
|
PP-C8 is a potent, selective CDK12-cyclin K complex PROTAC degrader with DC50 of DC50 of 416 nM and 412 nM for CDK12 and CycK protein levels respectively, does not affect CDK13. |
| PC-24107 |
ANXA3 degrader 18a5
ANXA3 degrader
|
ANXA3 degrader 18a5 is a highly selective ANXA3 degrader with SPR KD of 0.08 uM, exhibits antiproliferative activity against with IC50 of 0.71 and 1.05 uM, DC50 of 3.12 uM and 1.32 uM in MDA-MB-468 and MDA-MB-231 cells, respectively. |
| PC-24090 |
cGAS PROTAC TH35
cGAS degrader
|
cGAS PROTAC TH35 is an effective, selective CRBN-recruiting cGAS-targeting PROTAC degrader with DC50 of 0.9 uM and 4.6 uM in THP-1 and RAW 264.7 cells respectively, Dmax >90% at 20 uM. |
| PC-24083 |
SK2188
Aurora A PROTAC
|
SK2188 is a potent, highly selective PROTAC degrader of Aurora A with DC50 of 3.9 nM and Dmax of 89% in NGP neuroblastoma cells, induces subsequent reduction of MYCN. |
| PC-24082 |
JB170
Aurora A PROTAC
|
JB170 is a potent, highly selective PROTAC degrader of Aurora A with DC50 of 28 nM and Dmax of 300 nM in MV4-11 cells, linking alisertib to the cereblon-binding molecule Thalidomide. |
| PC-24081 |
JB300
Aurora A PROTAC
|
JB300 is a potent, highly selective PROTAC degrader of Aurora A with DC50 of 30 nM. |
