| Cat. No. |
Product Name |
Information |
| PC-25533 |
dHTC1
ENL degrader
|
dHTC1 (rac-dHTC1) is a potent, selective, and stereochemistry-dependent degrader of Eleven-Nineteen-Leukemia protein (ENL) with binding Kd of 45 nM for ENL, recruits CRL4CRBN to ENL through an extended interface of protein-protein and protein-ligand contacts, but only after pre-forming the ENL:dHTC1 complex. |
| PC-25493 |
FTO degrader FP54
FTO PROTAC
|
FTO degrader FP54 is a selective PROTAC degrader of fat mass and obesity-associated protein (FTO) with DCof 0.68 μM in NB4 cells and 0.71 μM in MOLM-13 cells, Dmax>95%. |
| PC-25407 |
ASP3082
KRAS G12D PROTAC
|
ASP3082 is a potent, selective KRAS G12D PROTAC degrader with DC50 of 38 nM, effectively induces KRAS(G12D) protein degradation with remarkable selectivity. |
| PC-25394 |
UNC10415667
NSD2 degrader
|
UNC10415667 is a potent, benzaldehyde containing NSD2 degrader with DC50 of 460 nM in NSD2 HiBit cells, recapitulates SCF FBXO22-dependent ubiquitination and potent degradation of NSD2. |
| PC-25389 |
AHPC(Me)-C6-NH2
FBXO22 degrader
|
AHPC(Me)-C6-NH2 is a potent, highly selective VHL-recruiting FBXO22 PROTAC degrader with DC50 of 77 nM in Jurkat cells, Dmax = 99%. |
| PC-25388 |
IKZF2 degrader 55
IKZF2 degrader
|
IKZF2 degrader 55 is a potent, selective IKZF2 degrader with DC50 of 1.8 nM by FACS assay in the Jurkat cells, Dmax=92%, shows minimal off-target activity against IMiD neo-substrates. |
| PC-25360 |
CDK2 degrader 37
CDK2 PROTAC
|
CDK2 degrader 37 is a potent, orally bioavailable and selective degrader of CDK2 with DC50 of 17 nM in CCNE1nonamp TOV21G cell line, >100-fold selectivity over CDK1, and >500-fold selectivity over CDK9. |
| PC-25336 |
ABT-002
GSPT1/NEK7 degrader
|
ABT-002 is the active metabolite of ABS-752, a potent molecular glue degrader of GSPT1 and NEK7, impairs the viability of HCC cell lines. |
| PC-25335 |
ABS-752 hydrochloride
GSPT1/NEK7 degrader
|
ABS-752 hydrochloride is a prodrug of ABT-002 that could be activated by the monoamine oxidase VAP-1, ABS-752 is a molecular glue degrader of GSPT1 and NEK7 with DC50 of 1 nM and 9 nM in Hep3B cells (24 h, Dmax>95%). |
| PC-25327 |
JWJ-01-334
ZBTB11 degrader
|
JWJ-01-334 is a negative control compound of JWJ-01-306. |
| PC-25326 |
JWJ-01-368
ZBTB11 degrader
|
JWJ-01-368 is a negative control compound of JWJ-01-306, which lacks the aromatic CF3 substituent crucial for achieving potent ZBTB11 degradation, efficiently binds CRBN but failed to promote both ZBTB11 ternary complex formation and ZBTB11 degradation. |
| PC-25325 |
JWJ-01-306
ZBTB11 degrader
|
JWJ-01-306 is a potent and selective molecular glue degrader of transcription factor ZBTB11 with DC50 of 620 nM, Dmax, 10 µM of 80%, in MIA PaCa-2 cells. |
