| Cat. No. |
Product Name |
Information |
| PC-60121 |
SNIPER(ABL)-062
BCR-ABL degrader
|
SNIPER(ABL)-062 is a novel, potent SNIPER molecule that tethers BCR-ABL inhibitor to a ligand of IAP, causes potent BCR-ABL degradation. |
| PC-60103 |
BETd-260 trifluoroacetate
BET PROTAC
|
BETd-260 trifluoroacetate (ZBC260, BETd 260 TFA) is a novel PROTAC BET degrader that tether HJB97 to a ligand for the E3 ubiquitin ligase VHL. |
| PC-60102 |
BETd-260
BET PROTAC
|
BETd-260 (ZBC260, BETd260) is a novel PROTAC BET degrader that tether HJB97 to a ligand for the E3 ubiquitin ligase VHL. |
| PC-60100 |
CDK9 PROTAC 1
CDK9 PROTAC
|
CDK9 PROTAC 1 is a heterobifunctional small molecule PROTAC capable of cereblon mediated proteasomal degradation of CDK9. |
| PC-60099 |
MZ1
BRD4 PROTAC
|
MZ1 is a PROTAC that tethers JQ1 to a ligand for the E3 ubiquitin ligase VHL, triggers and induces degradation of the BET bromodomain BRD4. |
| PC-60096 |
Sirt2 PROTAC 1
Sirt2 PROTAC
|
Sirt2 PROTAC 1 is a SirReal-based PROTAC that induces isotype-selective Sirt2 degradation (IC50=0.25 uM). |
| PC-42297 |
ARV-771
BET PROTAC
|
ARV-771 (ARV771) is a potent BET degrader (PROTAC), potently degrades BRD2/3/4 in 22Rv1 cells with DC50< 5 nM. |
| PC-45097 |
ARV-825
BRD4 PROTAC
|
ARV-825 is a hetero-bifunctional PROTAC (Proteolysis Targeting Chimera) that recruits BRD4 to the E3 ubiquitin ligase cereblon, leading to fast, efficient, and prolonged degradation of BRD4 via the proteasome. |
| PC-25719 |
BCL6 PROTAC A19
BCL6 PROTAC
|
BCL6 PROTAC A19 is a potent, selective BCL6 PROTAC degrader with DC50 of 0.034 nM and Dmax of 99% in OCI-LY1 cells. |
| PC-25704 |
LD5097
RIPK1 PROTAC
|
LD5097 is a potent, selective RIPK1 PROTAC degrader with DC50 of 0.7 nM in Jurkat cells, Dmax=96% (24h). |
| PC-25693 |
STAT6 PROTAC 1
STAT6 PROTAC
|
STAT6 PROTAC 1 is a potent, selective STAT6 PROTAC degrader with DC50 of <1 nM. |
| PC-25610 |
ZJK-807
KRAS G12D PROTAC
|
ZJK-807 is a selective, cereblon (CRBN)-based proteolysis-targeting chimera (PROTAC) degrader of KRASG12D with DC50 of 79.5 nM in AsPC-1 cells (Dmax=92%), with minimal impact on wild-type KRAS or other mutants (G12C/S/V, G13D) KRAS proteins. |
