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Chemical Structure : SHP2-D26
CAS No.: 2458219-65-1
Catalog No.: PC-38185Not For Human Use, Lab Use Only.
SHP2-D26 is a potent and effective SHP2 degrader (PROTAC) with DC50 of 6.0 and 2.6 nM in esophageal cancer KYSE520 and acute myeloid leukemia MV4.
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SHP2-D26 is a potent and effective SHP2 degrader (PROTAC) with DC50 of 6.0 and 2.6 nM in esophageal cancer KYSE520 and acute myeloid leukemia MV4;11 cells, respectively。
SHP2-D26 is >30-times more potent in inhibition of phosphorylation of extracellular signal-regulated kinase (ERK) and of cell growth than SHP099, a potent SHP2 inhibitor, in KYSE520 and MV4;11 cancer cell lines.
| M.Wt | 1115.896 | |
| Formula | C56H79ClN12O6S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(2S,4R)-1-((S)-2-(9-(4-(4-((3-((3-amino-5-(4-amino-4-methylpiperidin-1-yl)pyrazin-2-yl)thio)-2-chlorophenyl)amino)-4-oxobutanoyl)piperazin-1-yl)nonanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide |
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1. Wang M, et al. J Med Chem. 2020 Jul 23;63(14):7510-7528.
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