| Cat. No. |
Product Name |
Information |
| PC-72927 |
p62-ZZ ligand YTK-105
p62-ZZ ligand
|
YTK-105 is a small molecule p62-ZZ domain ligand, activate p62-dependent selective macroautophag, used for AUTOTAC design. |
| PC-72911 |
GNE-987
BET degrader
|
GNE-987 (GNE987) is a highly potent chimeric BET degrader, exhibits BRD4 degradation activity in EOL-1 AML cell line with DC50 of 30 pM. |
| PC-72840 |
MS9715
NSD3 PROTAC
|
MS9715 (MS 9715) is a NSD3-targeting PROTAC designed by linking BI-9321, a NSD3 antagonist, which binds NSD3's PWWP1 domain, with an E3 ligase VHL ligand. |
| PC-72837 |
NJH-2-057
CFTR DUBTAC
|
NJH-2-057 is a novel CFTR DUBTAC via linking the OTUB1 recruiter EN523 to the CFTR chaperone lumacaftor with C5 alkyl linkers. |
| PC-72798 |
AU-15330
SWI/SNF ATPase PROTAC
|
AU-15330 (AU15330) is a highly specific and VHL-dependent PROTAC degrader of SWI/SNF ATPase components (SMARCA2, SMARCA4 and PBRM1), shows preferential cytotoxicity in enhancer-binding transcription factor-addicted cancers at low nanomolar concentrations. |
| PC-72782 |
GSK215
FAK PROTAC
|
GSK215 is a potent, selective, FAK-degrading Proteolysis Targeting Chimera (PROTAC) based on a binder for the VHL E3 ligase and the known FAK inhibitor VS-4718. |
| PC-72644 |
CFT-2718
BRD4 PROTAC
|
CFT-2718 (CFT2718) is a benzotriazoloazepine-based BRD4 degrader, rapidly and selectively degrade BRD4 in vitro in a CRBN-dependent manner (DC90=10 nM, 293T cells). |
| PC-72621 |
ARV-471
ER degrader
|
ARV-471 (Vepdegestrant) is an investigational orally bioavailable PROTAC protein degrader designed to specifically target and degrade the estrogen receptor (ER) with DC50 of 1.8 nM. |
| PC-72572 |
SR-1114
ENL degarder
|
SR-1114 (SR1114) is a first-in-class ENL PROTAC degarder based on SR-0813 that binds to the E3 substrate adapter cereblon (CRBN), elicits rapid CRBN-dependent degradation of ENL with DC50 of 150 nM in MV4;11 cells. |
| PC-72497 |
INY-03-041
AKT PROTAC
|
INY-03-041 a pan-AKT degrader (PROTAC) consisting of AKT inhibitor GDC-0068 conjugated to lenalidomide, a recruiter of the E3 ubiquitin ligase substrate adaptor Cereblon (CRBN). |
| PC-72479 |
IRAK3 PROTAC 23
IRAK3 PROTAC
|
IRAK3 PROTAC 23 a potent and selective degrader of IRAK3 with DC50 of 2 nM, with a maximum degradation measured of 98%. |
| PC-72325 |
MS910
MEK1/2 degrader
|
MS910 (MS-910) is the first CRBN-recruiting MEK1/2 degrader (PROTC) with HT29 DC50 of 118/55 nM for MEK1/2 degradation, respectively. |
