| Cat. No. |
Product Name |
Information |
| PC-22391 |
WEE1 degrader 2
WEE1 degrader
|
WEE1 degrader 2 is a potent, selective CRBN-dependent WEE1 molecular glue degrader with DC50 of 140 nM and Emax of 85%, does not degrade CK1α. |
| PC-22390 |
WEE1 degrader 1
WEE1 degrader
|
WEE1 degrader 1 is a potent, selective CRBN-dependent WEE1 molecular glue degrader with DC50 of 91 nM, does not degrade CK1α. |
| PC-22382 |
ZNL-02-096
Wee1 degrader
|
ZNL-02-096 is a potent, selective CRBN-dependent Wee1 kinase degrader, induces potent and rapid Wee1 degradation, while sparing PLK1. |
| PC-22381 |
SKLB-0124
PRMT6 degrader
|
SKLB-0124 is a selective, first-in-class degrader for the protein arginine methyltransferase 6 (PRMT6) with EC50 of 15.4 uM for HCC827 cells. |
| PC-22356 |
GT-653
KDM5B degrader
|
GT-653 is a potent, selective and effective KDM5B PROTAC degrader based on CPI-455, induces KDM5B degradation via PROTAC mechanism and ubiquitin proteasome system dependent manner. |
| PC-22345 |
EP300 degrader MC-1
EP300 degrader
|
EP300 degrader MC-1 is a specific, bifunctional small molecule EP300 degrader, preferentially degrades EP300 in a proteasome-dependent manner, does not degrade CREBBP. |
| PC-22339 |
LLC355
DDR1 degrader
|
LLC355 is a potent DDR1 degrader and autophagosome-tethering compound (ATTEC) with DC50 of 150.8 nM in NCI-H23 cells, induce DDR1 degradation via lysosome-mediated autophagy, potently suppresses cancer cell tumorigenicity, migration, and invasion. |
| PC-22314 |
LC-MI-3
IRAK4 degrader
|
LC-MI-3 is a potent, selective and orally bioavailable PROTAC degrader of interleukin-1 receptor-associated kinase 4 (IRAK4) with DC50 of 47.3 nM in RAW264.7 cells, Dmax of 91%. |
| PC-22303 |
JYQ-194
PARK7 degrader
|
JYQ-194 (JYQ194) is a first-in-class, selective PARK7 PROTAC degrader, induces degradation of PARK7 starting at 0.1 uM and reaching a Dmax of 80% at a concentration of 5 uM in A549 cells. |
| PC-22257 |
LLC0424
NSD2 degrader
|
LLC0424 is a potent, selective, in vivo active NSD2 PROTAC degrader with DC50 of 20 nM, Dmax value of 96% in RPMI-8402 cells. |
| PC-22253 |
AKR1C3 PROTAC 5
AKR1C3 degrader
|
AKR1C3 PROTAC 5 is a first-in-class Aldo-Keto reductase 1C3 (AKR1C3) PROTAC degrader with DC50 of 52 nM in 22Rv1 cells, AKR1C1/C2 DC50 of 49 nM, ARv7 DC50 of 70 nM. |
| PC-22219 |
EBET-1593
BET degrader
|
EBET-593 is a bromodomain and extra-terminal (BET) protein degrader, effectively kills PDAC cells, and modulates cancer-associated fibroblasts (CAFs) in PDAC. |
