| Cat. No. |
Product Name |
Information |
| PC-20665 |
ARV-766
AR PROTAC
|
ARV-776 (Luxdegalutamide, ARV776) is potent, orally bioavailable PROTAC androgen receptor (AR) degrader that degrades not only wild-type AR but also clinically relevant AR LBD mutants, including the most prevalent AR L702H, H875Y, and T878A mutations. |
| PC-20560 |
NX-2127
BTK PROTAC
|
NX-2127 (NX2127) is a hetero-bifunctional, orally active PROTAC that induces the degradation of BTK and IKZF3 ubiquitination and proteasomal degradation in cells through recruitment of cereblon (CRBN). |
| PC-20466 |
BSJ-05-037
ITK PROTAC
|
BSJ-05-037 is a potent and selective heterobifunctional degrader of ITK with DC50 of 17.6-41.8 nM in TCL lines DERL-2 and Hut78. |
| PC-20464 |
BI 1810284
SMARCA2 PROTAC
|
BI 1810284 (ACBI2, BI 01810284) is a potent, selective and orally bioavailable VHL-recruiting PROTAC degrader of SMARCA2 (DC50=1 nM in RKO cells), 30-fold selectivity over SMARCA4. |
| PC-20356 |
UNC8153
NSD2 degrader
|
UNC8153 (UNC 8153) is a selective NSD2-targeted degrader with binding Kd of 24 nM for NSD2, potently and selectively reduces cellular levels of both NSD2 protein (DC50=350 nM) and H3K36me2 chromatin mark. |
| PC-20168 |
ZZ151
SOS1 degrader
|
ZZ151 (ZZ-151) is a highly potent and selective SOS1 degrader PROTAC with DC50 of 15.7 nM (Dmax=100%). |
| PC-20148 |
UNC7700
PRC2 degrader
|
UNC7700 (UNC-7700) is a potent EED-targeted PRC2 degrader, contains a unique cis-cyclobutane linker and potently degrades all PRC2 components EED (DC50=111 nM; Dmax=84%), EZH2WT/EZH2Y641N (DC50=275 nM; Dmax=86%) and SUZ12 (Dmax=44%) in DLBCL cells. |
| PC-20145 |
NVP-DKY709
IKZF2 degrader
|
NVP-DKY709 (DKY709) is a first-in-class, selective CRBN glue degrader of IKZF2 with DC50 of 4 nM in cellular assays, completely spares degradation of IKZF1/3. |
| PC-20007 |
GMB-475
BCR-ABL1 PROTAC
|
GMB-475 (GMB475) is an allosteric BCR-ABL1 PROTAC with DC50 of 340 nM, degrades the BCR-ABL1 through the ubiquitin-proteasome pathway. |
| PC-49672 |
MS3227
MDM2 PROTAC
|
MS3227 is a proteolysis-targeting chimera (PROTAC) that targets MDM2 by recruiting the E3 ligase VHL, resulting in proteasome-dependent degradation of MDM2. |
| PC-49629 |
AK-2292
STAT5 degrader
|
AK-2292 (AK2292) is a first, potent and selective small-molecule degrader of both STAT5A and STAT5B isoforms. |
| PC-49622 |
MS147
PRC1 degrader
|
MS147 (MS 147) is the first degrader of PRC1 core components, BMI1 and RING1B, comprises an EED small-molecule binder (EED226, Cat. PC-42321) linked to a ligand of the E3 ligase von Hippel-Lindau (VHL), degrades BMI1/RING1B in an EED-, VHL-, ubiquitination-, and time-dependent manner. |
