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Cat. No. Product Name Information
PC-23898

FTO PROTAC QP73

FTO degrader

FTO PROTAC QP73 is a first-in-class PROTAC degrader for the RNA demethylase FTO, efficiently induces FTO protein degradation in a dose-, time-, cereblon (CRBN)-, and proteasome-dependent manner in AML cells (DC50=34.9 nM, NB4 cells).
PC-23836

Gridegalutamide

AR degrader

Gridegalutamide (BMS-986409) is an orally bioavailable androgen receptor (AR) degrader, with potential antineoplastic activity.
PC-23772

HLB-0532259

Aurora-A PROTAC

HLB-0532259 is a potent, selective Aurora-A PROTAC degrader with DC50 of 20.2 nM in non-MYCN amplified MCF-7 cells.
PC-23702

CQ627

RIOK2 degrader

CQ627 is the first right open reading frame kinase 2 (RIOK2) molecular glue degrader with DC50 value of 410 nM and Dmax of 83.4% in MOLT4 leukemia cell line via UPS by recruiting E3 ubiquitin ligase RNF126.
PC-23444

SD-436

STAT3 PROTAC

SD-436 is a highly potent and selective STAT3 PROTAC degrader with DC50 of 10 nM and Dmax >95% in SU-DHL-1 lymphoma cell line.
PC-23408

MDEG-541

MYC PROTAC

MDEG-541 is a small molecule MYC PROTAC degrader, induces cereblon-dependent degradation of MYC, GSPT1/2, and PLK1.
PC-23403

MS105

PTK6 PROTAC

MS105 (YX39-105) is a potent, selective protein tyrosine kinase 6 (PTK6) PROTAC degrader, specifically and potently degrades PTK6 in a proteasome and VHL-dependent manner with DC50 of 21 nM and Dmax of 84% in MDA-MB-231/LM2-4 cells.
PC-23176

AK-1690

STAT6 PROTAC

AK-1690 is the first, potent and selective PROTAC STAT6 degrader with DC50 of 1 nM in MV4;11 cells, Dmax>95%.
PC-23149

YJ1206

CDK12/13 PROTAC

YJ1206 is a selective, orally bioavailable CDK12/13 PROTAC degrader, shows potent degradation effects and inhibits VCaP cell viability (IC50=12.5 nM).
PC-22955

MS8588

cGAS DUBTAC

MS8588 is a first-in-class DUBTAC of cGAS, a key component of the cGAS-STING pathway, stabilizes cGAS and increases the cGAS downstream effector protein STING.
PC-22954

MS7829

cGAS DUBTAC

MS7829 is a first-in-class DUBTAC of cGAS, a key component of the cGAS-STING pathway, stabilizes cGAS and increases the cGAS downstream effector protein STING.
PC-22897

HPK1 PROTAC C3

HPK1 PROTAC

HPK1 PROTAC C3 is a potent, selective and orally active HPK1 PROTAC degrader with DC50 of 21.26 nM, Dmax of 80.50% in Jurkat cells.

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