| Cat. No. |
Product Name |
Information |
| PC-25335 |
ABS-752 hydrochloride
GSPT1/NEK7 degrader
|
ABS-752 hydrochloride is a prodrug of ABT-002 that could be activated by the monoamine oxidase VAP-1, ABS-752 is a molecular glue degrader of GSPT1 and NEK7 with DC50 of 1 nM and 9 nM in Hep3B cells (24 h, Dmax>95%). |
| PC-25334 |
ABS-752
GSPT1/NEK7 degrader
|
ABS-752 is a prodrug of ABT-002 that could be activated by the monoamine oxidase VAP-1, ABS-752 is a molecular glue degrader of GSPT1 and NEK7 with DC50 of 1 nM and 9 nM in Hep3B cells (24 h, Dmax>95%). |
| PC-25288 |
UNC6587
TBK1 PROTAC
|
UNC6587 is a selective cereblon-based TBK1 proteolysis targeting chimera (PROTAC) degrader, efficiently eliminates TBK1 protein levels in ccRCC cells, while not affecting its close family member IKKε. |
| PC-24975 |
SD-91
STAT3 PROTAC
|
SD-91 is a potent, selective STAT3 PROTAC degrader with DC50 of 17 nM in SU-DHL-1 cell line. |
| PC-24854 |
YTHu78
KDM5B PROTAC
|
YTHu78 is a potent, selective CRBN ligand-based KDM5B PROTAC degrader, effectively induce KDM5B degradation in MV-4-11 and MM.1S cell lines, exhibits comparable degradation efficacy toward KDM5B and KDM5A. |
| PC-24668 |
BMS-986458
BCL6 degrader
|
BMS-986458 is a potent, highly selective, orally bioavailable CRL4 CRBN E3 ubiquitin ligase-dependent BCL6 ligand directed degrader with CRBN binding IC50 of 41 nM, and BCL-6 degradation of 0.2 nM in OCI-LY-1 cells (2 h). |
| PC-24667 |
PRT3789
SMARCA2 degrader
|
PRT3789 is a first-in-class potent and selective SMARCA2 (BRM) degrader with DC50 of 0.72 nM in Hela cells, effectively catalyze the polyubiquitination of specific lysine residues of SMARCA2, resulting in SMARCA2 selective degradation over SMARCA4. |
| PC-24632 |
MS9117
LSD1 PROTAC
|
MS9117 is a potent, selective CRBN-based LSD1 PROTAC degrader (DC50<40 nM in THP-1 cells), effectively degrades LSD1 in a concentration-, time-, and proteasome-dependent manner. |
| PC-24555 |
PLX-4545
IKZF2 degrader
|
PLX-4545 (PLX4545) is a potent and selective, orally bioavailable IKZF2 degrader, that depletes IKZF2 and converts suppressive Tregs into effector-like T-cells leading to antitumor immunity. |
| PC-24554 |
PVTX-405
IKZF2 degrader
|
PVTX-405 is a potent, highly selective, rapid and orally efficacious CRBN-dependent glue degrader of IKZF2 with DC50 of 0.7 nM in IKZF2 HiBiT degradation assay in HEK293 cells, Dmax = 91%. |
| PC-24472 |
KTX207
PDE4 PROTAC
|
KTX207 is a potent, selective BI 1015550-based PDE4 PROTAC degrader, degrades PDE4D and PDE4B shortforms in A549 cells with IC50 of 10 pM and 400 pM, respectively. |
| PC-24380 |
CDK2 degrader Cpd 1
CDK2 degrader
|
CDK2 degrader Cpd 1 is a potent, selective heterobifunctional CDK2 degrader with DC50 of <10 nM and Dmax>90% in TOV21G cells, 1,000-fold selectivity versus CDK1. |
