| Cat. No. |
Product Name |
Information |
| PC-27503 |
Sovutrecdeg
TRK degrader
|
Sovutrecdeg (CG001419) is a first-in-class, selective, potent oral degrader of pan-tropomyosin receptor kinase (TRK), selectively degrades both mutant and wild-type TRK proteins. |
| PC-27493 |
Reziciclideg
CDK4/6 degrader
|
Reziciclideg (BTX-9341) is a potent, seletive, blood-brain barrier permeable cereblon-mediated bifunctional degrader of CDK4 and CDK6 with Kd of 31 nM (CDK6). |
| PC-27488 |
SIAIS164018 hydrochloride
Multi-kinases PROTAC
|
SIAIS164018 hydrochloride is a potent, Brigatinib-based PROTAC degrader of multi-kinases ALK, EGFR, FAK, PYK2, PTK6 with IC50 of 2.5 nM and 6.6 nM against ALK and ALK (G1202R), respectively, promotes the ubiquitination and degradation of ALK, EGFR, FAK, PYK2 and PTK6, induces cell cycle arrest at the G1 phase and triggers cell apoptosis. |
| PC-27487 |
SIAIS164018
Multi-kinases PROTAC
|
SIAIS164018 is a potent, Brigatinib-based PROTAC degrader of multi-kinases ALK, EGFR, FAK, PYK2, PTK6 with IC50 of 2.5 nM and 6.6 nM against ALK and ALK (G1202R), respectively, promotes the ubiquitination and degradation of ALK, EGFR, FAK, PYK2 and PTK6, induces cell cycle arrest at the G1 phase and triggers cell apoptosis. |
| PC-27486 |
Omtebrutideg
BTK PROTAC
|
Omtebrutideg is a potent and selective BTK PROTAC degrader. |
| PC-27441 |
YTHDC1 PROTAC XY-2
YTHDC1 degrader
|
YTHDC1 PROTAC XY-2 is a selective, efficient PROTAC degrader of N6-Methyladenosine (m6A) reader YTHDC1 with DC50 of 11.42 nM in MOLM13 and 13.59 nM in Kasumi-1 cells respectively. |
| PC-27298 |
SK-575
PARP1 PROTAC
|
SK-575 is a highly potent, selective PARP1 PROTAC degrader with IC50 of 2.3 nM, potently inhibits cancer cell growth of bearing BRCA1/2 mutations and induces potent and specific degradation of PARP1 in various human cancer cells even at low picomolar concentrations. |
| PC-27259 |
SD-2301
STAT3 PROTAC
|
SD-2301 is a highly potent, selective, and efficacious STAT3 PROTAC degrader with DC50 of 4 nM, Dmax of >95% in HiBiT assays using HeLa cell line. |
| PC-27200 |
JHK-02-108-2
CDK6 PROTAC
|
JHK-02-108-2 is a potent, selective, type II, heterobifunctional CDK6 PROTAC degrader with DC50 of 11 nM in MOLT-4 cells, does not induce CDK5 degradation. |
| PC-27186 |
dIRF4-2
IRF4 PROTAC
|
dIRF4-2 is a first-in-class, highly seletive proteolysis-targeting chimera (PROTAC) degrader of interferon regulatory factor 4 (IRF4) with DC50 of 2.3 µM and 2.2 µM for OPM2 and MM1.S, respectively (4h). |
| PC-27164 |
RAD51 PROTAC G73
RAD51 PROTAC
|
RAD51 PROTAC G73 is an effective RAD51 PROTAC degrader with DC50 of 268 nM in PC-3 cells. |
| PC-27137 |
XYD113
GSPT1 degrader
|
XYD113 is a potent and highly selective, orally bioavailable CRBN-dependent GSPT1 molecular glue degrader, exerts potent antiproliferative activity against 22Rv1 cells with IC50 of 69 nM, induces complete degradation of GSPT1 at 111 nM. |
