| Cat. No. |
Product Name |
Information |
| PC-22120 |
ARV-393
BCL6 PROTAC
|
ARV-393 is a potent, orally bioavailable BCL6 targeting PROTAC degrader with DC50 and GI50 values <1 nM in numerous DLBCL and BL cell lines. |
| PC-22117 |
BMS-986365
AR degrader
|
BMS-986365 (CC-94676) is a highly potent and selective androgen receptor (AR) degrader with DC50 of 10-40 nM, induces rapid and deep degradation of both wildtype and mutant forms of AR. |
| PC-22055 |
AU-24118
mSWI/SNF ATPase PROTAC
|
AU-24118 is a potent, selective, and orally bioavailable degrader of mSWI/SNF ATPases (SMARCA2, SMARCA4) and PBRM1. |
| PC-21928 |
Dual BCL-xL, BCL-2 degrader 753b
BCL-xL/BCL-2 PROTAC
|
Dual BCL-xL/BCL-2 degrader 753b (Compound 753b) is a highly potent dual BCL-xL and BCL-2 PROTAC degrader with DC50 of 6 nM and 48 nM for degrading BCL-xL and BCL-2 in 293T cells respectively. |
| PC-21848 |
GNE-0011
BRD4 degrader
|
GNE-0011 is a monovalent, JQ1-based BRD4 degrader that is not linked to an E3 ligase binder, triggers proteasomal and ubiquitin-dependent selective degradation of BRD4 over BRD2 and BRD3. |
| PC-21676 |
WD6305
METTL3-METTL14 PROTAC
|
WD6305 is a potent and selective proteolysis-targeting chimera (PROTAC) degrader of METTL3-METTL14 complex with DC50 of 140 nM (METTL3), Dmax of 91.9% in Mono-Mac-6 AML cell line. |
| PC-21662 |
ACBI3
pan-KRAS PROTAC
|
ACBI3 is a selective, potent and in vivo active pan-KRAS PROTAC degrader, potently degrades 13 out of 17 of the most prevalent oncogenic KRAS alleles (DC50=3.9 nM in GP2d cells). |
| PC-21653 |
DAS-CHO-5-oCRBN
c-Src PROTAC
|
DAS-CHO-5-oCRBN is a potent and selective PROTAC for c-Src kinase with DC50 value of 55 nM in CAL148 cells. |
| PC-21567 |
BGB-16673
BTK PROTAC
|
BGB-16673 is an orally available heterobifunctional BTK PROTAC degrader that binds to BTK and E3 ligase, degrades wildtype BTK and multiple mutant forms via ubiquitination. |
| PC-21533 |
KH-103
GR PROTAC
|
KH-103 is a highly potent, catalytically-driven glucocorticoid receptor (GR) PROTAC degrader, demonstrate excellent performance in passively preventing ligand-induced gene expression activation in the absence of partial agonistic transcriptional triggering and crosstalk inhibition. |
| PC-21507 |
MS132
WDR5 PROTAC
|
MS132 is a highly potent and selective VHL-recruiting WDR5 PROTAC degrader with DC50 of 92 nM in MIA PaCa-2 cells. |
| PC-21468 |
PIK5-12d
PIKfyve PROTAC
|
PIK5-12d is a highly potent, selective, first-in-class PIKfyve PROTAC degrader, potently degrades PIKfyve protein with DC50 value of 1.48 nM and Dmax value of 97.7% in prostate cancer VCaP cells. |
