AMPTX1

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Chemical Structure : AMPTX1

Catalog No.: PC-25674Not For Human Use, Lab Use Only.

AMPTX-1 is a potent, selective and reversibly covalent BRD9 degrader with DC50 of 0.5 nM and Dmax =93% (MV4-11 cell, 6h).

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

AMPTX-1 is a potent, selective and reversibly covalent BRD9 degrader with DC50 of 0.5 nM and Dmax =93% (MV4-11 cell, 6h).
AMPTX-1 covalently recruits DCAF16:DDB1 complex to BRD9.
AMPTX-1-induced BRD9 degradation is dependent on the DCAF16 Cullin RING E3 ligase.
AMPTX-1 induces sustained BRD9 protein degradation in a xenograft model.

Physicochemical Properties

M.Wt	691.92
Formula	C42H53N5O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(5-((7-(2,6-dimethoxy-4-(1,4,5-trimethyl-6-oxo-1,6-dihydropyridin-3-yl)benzyl)-4,7-diazaspiro[2.5]octan-4-yl)methyl)-1-methyl-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)-4,4-dimethylpent-2-enenitrile

References

1. Hughes SJ, et al. Nat Commun. 2025 Oct 27;16(1):8516.

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AMPTX1

Biological Activity

Physicochemical Properties

References

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