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Cat. No. Product Name Information
PC-24278

TO-1187

HDAC6 PROTAC

TO-1187 is a potent, selective, cereblon (CRBN)-based HDAC6 PROTAC degrader with DC50 of 5.81 nM in MM.1S cells (6 h), Dmax of 94%.
PC-24265

HDAC6 PROTAC 17c

HDAC6 PROTAC

HDAC6 PROTAC 17c is a potent, selective CRBN- and VHL-recruiting PROTAC degrader of HDAC6 with DC50 of 14 nM in MM.1S cells, Dmax of 91%, high selective over other HDACs.
PC-24242

BT-O2C

p300 PROTAC

BT-O2C is a potent, selective PROTAC degrader of p300, potently degrades p300 while sparing CBP, is cytotoxic in CIC::DUX4 sarcoma (CDS) cell lines (IC50=152-221 nM).
PC-24233

PP-C8

CDK12 PROTAC

PP-C8 is a potent, selective CDK12-cyclin K complex PROTAC degrader with DC50 of DC50 of 416 nM and 412 nM for CDK12 and CycK protein levels respectively, does not affect CDK13.
PC-24107

ANXA3 degrader 18a5

ANXA3 degrader

ANXA3 degrader 18a5 is a highly selective ANXA3 degrader with SPR KD of 0.08 uM, exhibits antiproliferative activity against with IC50 of 0.71 and 1.05 uM, DC50 of 3.12 uM and 1.32 uM in MDA-MB-468 and MDA-MB-231 cells, respectively.
PC-24090

cGAS PROTAC TH35

cGAS degrader

cGAS PROTAC TH35 is an effective, selective CRBN-recruiting cGAS-targeting PROTAC degrader with DC50 of 0.9 uM and 4.6 uM in THP-1 and RAW 264.7 cells respectively, Dmax >90% at 20 uM.
PC-24083

SK2188

Aurora A PROTAC

SK2188 is a potent, highly selective PROTAC degrader of Aurora A with DC50 of 3.9 nM and Dmax of 89% in NGP neuroblastoma cells, induces subsequent reduction of MYCN.
PC-24082

JB170

Aurora A PROTAC

JB170 is a potent, highly selective PROTAC degrader of Aurora A with DC50 of 28 nM and Dmax of 300 nM in MV4-11 cells, linking alisertib to the cereblon-binding molecule Thalidomide.
PC-24081

JB300

Aurora A PROTAC

JB300 is a potent, highly selective PROTAC degrader of Aurora A with DC50 of 30 nM.
PC-24058

RDN8011

KDM4 PROTAC

RDN8011 is a potent, selective first-in-class PROTAC degrader of KDM4 with DC50 of 37-50 nM for KDM4A/KDM4B/KDM4C in in KYSE-150 cells, while sparing KDM4D.
PC-24047

KT-333

STAT3 degrader

KT-333 (KT333) is a potent, highly specific potent heterobifunctional PROTAC degrader of STAT3 with DC50 of 2.5 -11.8 nM in anaplastic T cell lymphoma (ALCL) lines.
PC-24046

CDK9 PROTAC C3

CDK9 degrader

CDK9 PROTAC C3 is a potent and selective, oral CDK9 PROTAC degrader with DC50 of 1.09 nM in NCI-H69 cells.

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