| Cat. No. |
Product Name |
Information |
| PC-26385 |
JP-2-197
BRD4 degrader
|
JP-2-197 is a fumarate-based RNF126-dependent BRD4 degrader, induces robust degradation of both long and short BRD4 isoforms in RNF126 wild-type cells but not in RNF126 knockout cells. |
| PC-26370 |
HDAC3 degrader GS-1
HDAC3 degrader
|
GS-1 is a potent, selective HDAC3 degrader with DC50 of 1.24 uM in THP-1 cells, shows minimal degradation of HDAC1 or HDAC2 at 5 uM. |
| PC-26347 |
Orevandrodeg
Ligand-directed degrader
|
Orevandrodeg (BMS-986460, CC-2043137) is a ligand-directed degrader composed of an E3 ubiquitin ligase-binding moiety that is conjugated, via a linker, to a moiety that targets a prostate specific tumor-associated antigen (TAA), with potential antineoplastic activity, androgen receptor degradation inducer. |
| PC-26284 |
DZ-865B
BCL6 PROTAC
|
DZ-865B is a selective BCL6 degrader with DC50 of 2.7 uM and 4.7 uM in DLBCL cell lines OCI-LY-1 and SU-DHL-4 respectively, effectively suppresses DLBCL cell growth. |
| PC-26247 |
DFCI-002-06
HCK/BTK PROTAC
|
DFCI-002-06 is a potent, first-in-class dual HCK/BTK PROTAC degrader with DC50 values of 4.5 nM for BTK and 1.3 nM for HCK, Dmax values of >95% for BTK and 87% for HCK. |
| PC-26238 |
USP39_PROTAC_V1
USP39 PROTAC
|
USP39_PROTAC_V1 is a potent, selective VHL‐based PROTAC degrader of USP39 with KD of 232 nM, DC50 of 1 nM in HeLa cells. |
| PC-26228 |
ITRI-148
AR-NTD PROTAC
|
ITRI-148 is a CRBN-based androgen receptor N-terminal domain (AR-NTD) degrader, degrades AR, AR-V7, and AR mutants with DC50 of 0.05 uM and 0.02 uM for AR and AR-V7in VCaP cells. |
| PC-26219 |
XYD270
BRD9 PROTAC
|
XYD270 is a potent, selective, and orally efficacious BRD9 PROTAC degrader with DC50 of 0.082 nM and 3.9 nM in HS-SY-II cells and MV4;11 cells respectively. |
| PC-26139 |
KTX-951
IRAK4 PROTAC
|
KTX-951 is a potent and orally active degrader of IRAK4 and the Ikaros and Aiolos (IMiD) substrates with DC50 of 13 nM, 14 nM and 13 nM for IRAK4, Ikaros and Aiolos, respectively, induces proteasomal degradation of these key proteins, leading to the dual inhibition of the NF-κB and IRF4 signaling pathways. |
| PC-26138 |
KTX-582
IRAK4 PROTAC
|
KTX-582 is a potent, selective IRAK4 PROTAC degrader with DC50 values of 4 nM and 5 nM for IRAK4 and Ikaros, respectively, induces apoptosis in MYD88MT DLBCL, induces in vivo tumor regressions in lymphoma model. |
| PC-26133 |
GDCNF-11
GPX4 degrader
|
GDCNF-11 is a potent HSP90 interactome-mediated proteolysis targeting chimera (HIM-PROTAC) GPX4 degarder, potently induces ferroptosis via HSP90-mediated ubiquitin-proteasomal degradation of GPX4 in HT-1080 cells with DC50 of 0.08 uM. |
| PC-26131 |
GDAz-3
GPX4 degrader
|
GDAz-3 is a potent GPX4-targeting HSP70-PROTAC, potently and rapidly eliminates GPX4 in HT1080 cells (DC50=0.13 uM), thereby triggering ferroptosis with high selectivity. |
