| Cat. No. |
Product Name |
Information |
| PC-60100 |
CDK9 PROTAC 1
CDK9 PROTAC
|
CDK9 PROTAC 1 is a heterobifunctional small molecule PROTAC capable of cereblon mediated proteasomal degradation of CDK9. |
| PC-60099 |
MZ1
BRD4 PROTAC
|
MZ1 is a PROTAC that tethers JQ1 to a ligand for the E3 ubiquitin ligase VHL, triggers and induces degradation of the BET bromodomain BRD4. |
| PC-60096 |
Sirt2 PROTAC 1
Sirt2 PROTAC
|
Sirt2 PROTAC 1 is a SirReal-based PROTAC that induces isotype-selective Sirt2 degradation (IC50=0.25 uM). |
| PC-42297 |
ARV-771
BET PROTAC
|
ARV-771 (ARV771) is a potent BET degrader (PROTAC), potently degrades BRD2/3/4 in 22Rv1 cells with DC50< 5 nM. |
| PC-45097 |
ARV-825
BRD4 PROTAC
|
ARV-825 is a hetero-bifunctional PROTAC (Proteolysis Targeting Chimera) that recruits BRD4 to the E3 ubiquitin ligase cereblon, leading to fast, efficient, and prolonged degradation of BRD4 via the proteasome. |
| PC-26692 |
M4K3250
ALK2 degrader
|
M4K3233 is a potent, selective first-in-class ALK2 degrader with pDC50 of 7.9 in HEK-293 cells and Dmax=78%, induces ALK2 degradation via a CRBN-mediated, ubiquitin, proteasome/lysosome combinatorial pathway. |
| PC-26691 |
M4K3233
ALK2 degrader
|
M4K3233 is a potent, selective first-in-class ALK2 degrader with pDC50 of 7.3 in HEK-293 cells, induces ALK2 degradation via a CRBN-mediated, ubiquitin, proteasome/lysosome combinatorial pathway. |
| PC-26688 |
Polθ degrader 1
DNA Polθ degrader
|
Polθ degrader 1 is a potent efficient degrader of DNA polymerase theta (Polθ). |
| PC-26648 |
LD5095
RIPK1 PROTAC
|
LD5095 is a potent, selective cereblon (CRBN)-recruiting RIPK1 degrader with DC50 of 1.4, 1.2, and 2.3 nM and Dmax>90% for endogenous RIPK1 in WT Jurkat, MOLM14, and U937 cell lines. |
| PC-26640 |
MS108
ENL PROTAC
|
MS108 is a potent, selective eleven-nineteen leukemia protein (ENL) PROTAC degrader with DC50 of 0.6 nM and Dmax > 97% in MV4;11 cells. |
| PC-26578 |
BMS-986482
IKZF1-4 degrader
|
BMS-986482 is a rapid, selective, CRBN-dependent pan-degrader of IKZF transcription factor family members, induces robust tumor growth inhibition. |
| PC-26534 |
TKP-5
BRD4 degrader
|
TKP-5 is a highly potent BRD4 PROTAC degrader with DC50 of 16.78 nM in mouse keratinocyte cell line KCMH-1, Kd of 150 nM for BRD4-BD1, exhibits inhibitory activity against TSLP expression. |
