| Cat. No. |
Product Name |
Information |
| PC-42297 |
ARV-771
BET PROTAC
|
ARV-771 (ARV771) is a potent BET degrader (PROTAC), potently degrades BRD2/3/4 in 22Rv1 cells with DC50< 5 nM. |
| PC-45097 |
ARV-825
BRD4 PROTAC
|
ARV-825 is a hetero-bifunctional PROTAC (Proteolysis Targeting Chimera) that recruits BRD4 to the E3 ubiquitin ligase cereblon, leading to fast, efficient, and prolonged degradation of BRD4 via the proteasome. |
| PC-26534 |
TKP-5
BRD4 degrader
|
TKP-5 is a highly potent BRD4 PROTAC degrader with DC50 of 16.78 nM in mouse keratinocyte cell line KCMH-1, Kd of 150 nM for BRD4-BD1, exhibits inhibitory activity against TSLP expression. |
| PC-26524 |
MGD-28
IKAROS protein degrader
|
MGD-28 is a potent, orally active CRBN-dependent IKAROS protein degrader that degrades IKZF1 (DC50=3.8 nM), IKZF2 (DC50=56.3 nM), and IKZF3 (DC50=7.1 nM), also degrades CK1α (DC50=7.8 nM). |
| PC-26523 |
PVTX-321
ERα degrader
|
PVTX-321 is a potent and orally bioavailable estrogen receptor α (ERα) heterobifunctional degrader with DC50 of 0.15 nM, Dmax = 81% in MCF7 cells. |
| PC-26522 |
IKZF2 degrader 25
IKZF2 degrader
|
IKZF2 degrader 25 is a potent, highly selective, and orally efficacious IKZF2 degrader with DC50 of 1.78 nM (Dmax = 93.2%, HEK293T cells), with minimal IKZF1/3 degradation. |
| PC-26520 |
UNC8209
TBK1 PROTAC
|
UNC8209 is a a selective cereblon-recruiting PROTAC degrader of TANK-binding kinase 1 (TBK1) with DC50 of 80 nM and 23 nM in A498 and 769-P cells respectively. |
| PC-26509 |
TED-690
TEAD·YAP/TAZ PROTAC
|
TED-690 is a potent, heterobifunctional TEAD·YAP/TAZ PROTAC degrader, degrades YAP, pYAPS127, and active YAP protein levels with DC50 values of 0.1 μM (Dmax=57%), 0.1 μM (Dmax=80%), and 0.01 uM (Dmax=80%) in MDA-MB-231 cells, also degrades partners YAP and TAZ. |
| PC-26501 |
CDK6 PROTAC CP-10
CDK6 PROTAC
|
CDK6 PROTAC CP-10 is a potent, selective CDK6 degrader (DC50=2.1 nM, U251 cells) generated by linking CDK6 inhibitor palbociclib and E3 ligase CRBN recruiter pomalidomide. |
| PC-26498 |
Cyclin D1 degrader MS28
Cyclin D1 degrader
|
Cyclin D1 degrader MS28 (XY028-133) is a potent, selective and first-in-class PROTAC degrader of cyclin D1 through recruiting the CDK4/6-cyclin D1 complex to VHL E3 ligase, effectively degrades cyclin D1 in Calu-1 cells with DC50 of 950 nM and Dmax of 90% (8 h). |
| PC-26461 |
CXJ2080
CDK7 PROTAC
|
CXJ2080 is a potent, selective CDK7 PROTAC degrader with DC50 of 0.88 nM and Dmax >98% in MV4-11 cells, disrupts the CDK7-cyclin H-MAT1 complex, simultaneously suppressing MYC-driven oncogenic signaling while activating the p53-p21 tumor suppressor axis. |
| PC-26457 |
KRAS G12C PROTAC LC-2
KRAS G12C PROTAC
|
KRAS G12C PROTAC LC-2 is a potent, selective VHL-Recruiting PROTAC degrader of KRASG12C with DC50 of 0.59 uM and Dmax of 80% in NCI-H2030 cells. |
