Chemical Structure : PLX-4545
CAS No.:
2892065-45-9
PLX-4545
(PLX4545)
Catalog No.: PC-24555Not For Human Use, Lab Use Only.
PLX-4545 (PLX4545) is a potent and selective, orally bioavailable IKZF2 degrader, that depletes IKZF2 and converts suppressive Tregs into effector-like T-cells leading to antitumor immunity.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
PLX-4545 (PLX4545) is a potent and selective, orally bioavailable IKZF2 degrader, that depletes IKZF2 and converts suppressive Tregs into effector-like T-cells leading to antitumor immunity.
Oral administration of PLX-4545 resulted in dose dependent depletion of IKZF2 and single agent antitumor activity in vivo.
PLX-4545 treatment preferentially converted tumor Tregs into effector-like T-cells through decreased CD25 expression and increased production of effector cytokines (IL2, IFNγ), resulting in increased infiltration of CD4/8 Teff cells into tumor tissue.
Combination of PLX-4545 with anti-PD1 significantly increased the proliferation of Teff cells and inhibition of tumor growth in vivo.
Physicochemical Properties
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M.Wt
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473.57
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Formula
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C28H31N3O4
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(S)-3-(1-oxo-5-(((1S,2S)-2-(3-phenylazetidin-1-yl)cyclohexyl)oxy)isoindolin-2-yl)piperidine-2,6-dione
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References
1. Yujun Huang, et al. Cancer Res (2025) 85 (8_Supplement_1): 6380.
2. Chen Z, et al. Nat Commun. 2025 May 1;16(1):4095.
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