| Cat. No. |
Product Name |
Information |
| PC-38182 |
SHP2 PROTAC R1-5C
SHP2 PROTAC
|
SHP2 PROTAC R1-5C is a potent and highly selective SHP2 PROTAC created by conjugating RMC-4550 with pomalidomide using a PEG linker, with a low nanomolar DC50. |
| PC-38058 |
BSJ-4-116
CDK12 degrader
|
BSJ-4-116 is a potent, CDK12 specific degrader (PROTAC) with IC50 of 6 nM, exhibits anti-proliferative activity in cancer cells. |
| PC-38054 |
DT2216
BCL-XL PROTAC
|
DT2216 (DT-2216) is a specific BCL-XL PROTAC by linking ABT263 to a VHL ligand (VHL-L), induces BCL-XL degradation in MOLT-4 T-ALL cells with DC50 of 63 nM. |
| PC-38047 |
Bavdegalutamide
AR PROTAC
|
Bavdegalutamide (ARV-110) is an orally bioavailable, specific androgen receptor (AR) PROTAC degrader that leads to ubiquitination and degradation of AR with DC50 of <1 nM. |
| PC-38019 |
dCBP-1
p300/CBP PROTAC
|
dCBP-1 is a potent, selective chemical degrader of p300/CBP based on PROTAC. |
| PC-36168 |
Rpn13 degrader WL40
Rpn13 PROTAC
|
Rpn13 degrader WL40 (WL40) is a novel covalent ubiquitin receptor Rpn13 degrader by linking the Rpn13 covalent inhibitor RA190 with the cereblon (CRBN) binding ligand thalidomide. |
| PC-36151 |
NRX-252114
|
NRX-252114 (NRX 252114, NRX252114) is a potent, small molecule β-TrCP-based degrader of β-catenin, potentiates pSer33/S37A β-catenin binding and ubiquitylation (EC50=6.5 nM). |
| PC-36067 |
BI-3663
FAK PROTAC
|
BI-3663 (BI 3663) is a cereblon-based degrader (PROTAC) of Focal adhesion tyrosine kinase (PTK2/FAK) with a median DC50 of 30 nM to >80% across a panel of eleven HCC cell lines. |
| PC-35936 |
BSJ-03-123
CDK6 PROTAC
|
BSJ-03-123 is a potent, CDK6-selective small-molecule degrader (PROTAC) that uniquely enables rapid pharmacological interrogation of CDK6-dependent functions. |
| PC-35884 |
DD-03-171
BTK degrader
|
DD-03-171 is a small molecule, CGI1746-based BTK degrader (PROTAC, biochemical IC50=5.1 nM) that efficiently degrade C481S-BTK, exhibits enhanced anti-proliferative effects on mantle cell lymphoma (MCL) cells in vitro by degrading BTK, IKFZ1 and IKFZ3. |
| PC-35882 |
VZ185
BRD9 PROTAC
|
VZ185 (VZ-185) is a potent, fast and selective, VHL-based dual degrader probe (PROTAC) of BRD9 and BRD7 with DC50 of 1.8 and 4.5 nM, respectively. |
| PC-35859 |
FKBP12 PROTAC dTAG-13
FKBP12 degrader
|
FKBP12 PROTAC dTAG-13 (dTAG-13) is an in vivo-active heterobifunctional adation tag (dTAG) small molecule that engage FKBP12F36V and CRBN, selectively degrade FKBP12F36V in a CRBN-dependent manner in cells. |
