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INY-05-040

Chemical Structure : INY-05-040

CAS No.: 2503018-29-7

INY-05-040

Catalog No.: PC-24888Not For Human Use, Lab Use Only.

INY-05-040 is a second-generation pan-AKT PROTAC degrader, selectively and rapidly (<5 h) degrades all three AKT isoforms and inhibits downstream signaling and cell proliferation in 288 cancer cell lines.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

INY-05-040 is a second-generation pan-AKT PROTAC degrader, selectively and rapidly (<5 h) degrades all three AKT isoforms and inhibits downstream signaling and cell proliferation in 288 cancer cell lines.

Physicochemical Properties

M.Wt 1026.78
Formula C55H76ClN9O6S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(2S,4R)-1-((S)-2-(11-(((S)-2-(4-chlorophenyl)-3-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-oxopropyl)amino)undecanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide

References

1. Emily C Erickson, et al. Sci Signal. 2024 Feb 27;17(825):eadf2670.

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