Chemical Structure : INNO-220
CAS No.:
3032577-24-2
INNO-220
(INNO220)
Catalog No.: PC-24767Not For Human Use, Lab Use Only.
INNO-220 is a highly selective and potent, CRBN-dependent, orally bioavailable degrader of CK1α without affecting IKZF1/3, impairs cell viability and selectively degraded CK1α in lymphoma cells.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
INNO-220 is a highly selective and potent, CRBN-dependent, orally bioavailable degrader of CK1α without affecting IKZF1/3, impairs cell viability and selectively degraded CK1α in lymphoma cells.
INNO-220 inhibits cells harboring wild-type p53 and exhibiting constitutive NF-κB signaling.
INNO-220 inhibits IL-2 expression by disrupting the CBM complex and inhibiting NF-κB activity.
INNO-220 suppresses NF-κB signaling and activates p53 pathway, leading to complete inhibition of lymphoma tumor growth in vivo.
INNO-220 disrupts the assembly and function of the CARD11/BCL10/MALT1 complex, thereby inhibiting NF-κB signaling in stimulated T cells and lymphoma cells that harbor an activating mutation in CARD11.
Physicochemical Properties
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M.Wt
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400.44
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Formula
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C23H20N4O3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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3-(5-(1-Methyl-5-phenyl-1H-pyrazol-4-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione
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References
1. Feng S, et al. Leukemia. 2025 May 27. doi: 10.1038/s41375-025-02647-x.
2. Patent WO2024054832 A1.
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