YT-58 | BTK PROTAC | Probechem Biochemicals

Chemical Structure : YT-58

YT-58 (RBBP7-recruiting BTK PROTAC degrader)

Catalog No.: PC-24930Not For Human Use, Lab Use Only.

YT-58 is a selective, RBBP7-recruiting BTK PROTAC degrader with DC50 of 0.17 uM (Dmax=83%), induces BTK degradation via the proteasome pathway and effectively inhibits BTK and PLCγ2 phosphorylation.

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Biological Activity

YT-58 is a selective, RBBP7-recruiting BTK PROTAC degrader with DC50 of 0.17 uM (Dmax=83%), induces BTK degradation via the proteasome pathway and effectively inhibits BTK and PLCγ2 phosphorylation.
Covalent modification of RBBP7 C97 is critical for YT-58-mediated BTK degradation.

Physicochemical Properties

M.Wt	706.87
Formula	C38H42N8O4S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-N-(6-(3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)hexyl)-4-(N-ethynyl-N-methylsulfamoyl)benzamide

References

1. Liu Y, et al. Angew Chem Int Ed Engl. 2025 Jul 2:e202508538.

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YT-58 (RBBP7-recruiting BTK PROTAC degrader)

Biological Activity

Physicochemical Properties

References

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