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BMS-986458

Chemical Structure : BMS-986458

CAS No.: 3005272-36-3

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BMS-986458 (BMS986458)

Catalog No.: PC-24668Not For Human Use, Lab Use Only.

BMS-986458 is a potent, highly selective, orally bioavailable CRL4 CRBN E3 ubiquitin ligase-dependent BCL6 ligand directed degrader.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

BMS-986458 is a potent, highly selective, orally bioavailable CRL4 CRBN E3 ubiquitin ligase-dependent BCL6 ligand directed degrader.
BMS-986458 rapidly degrades BCL6 protein to levels that drive broad anti-tumor effects in 80% of BCL6 expressing NHL cell lines and all ex vivo patient derived xenograft (PDX) models evaluated.

Physicochemical Properties

M.Wt 628.13
Formula C32H34ClN9O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2,6-Piperidinedione, 3-[6-[[(3R,4R)-1-[5-chloro-4-[(2,3-dihydro-1-methyl-2-oxo-1H-indol-5-yl)amino]-2-pyrimidinyl]-3-methyl-4-piperidinyl]amino]-1-methyl-1H-indazol-3-yl]-

References

1. Lynda Groocock, et al. Blood. Volume 144, Supplement 1, 5 November 2024, Page 957.

2. Patent WO2023212147 A1.

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