SJ46420

Chemical Structure : SJ46420

Catalog No.: PC-24903Not For Human Use, Lab Use Only.

SJ46420 is the a methyl-ester prodrug of SJ46421 and specific JQ1-based KLHDC2 PROTAC protein degrader of BRD3, induces selective BRD3 degradation in PC3 cells with DC50 of 487 nM (Dmax=99%).

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Biological Activity

SJ46420 is the a methyl-ester prodrug of SJ46421 and specific JQ1-based KLHDC2 PROTAC protein degrader of BRD3, induces selective BRD3 degradation in PC3 cells with DC50 of 487 nM (Dmax=99%).

Physicochemical Properties

M.Wt	851.44
Formula	C43H43ClN8O5S2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	methyl (S)-(2-(2-(8-(2-(4-(2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetyl)piperazin-1-yl)ethoxy)naphthalen-2-yl)thiazol-4-yl)acetyl)glycinate

References

1. Scott DC, et al. Nat Commun. 2024 Oct 12;15(1):8829.

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SJ46420

Biological Activity

Physicochemical Properties

References

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