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NK7-902

Chemical Structure : NK7-902

CAS No.:

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NK7-902

Catalog No.: PC-24938Not For Human Use, Lab Use Only.

NK7-902 is a potent and selective cereblon (CRBN) glue degrader of NEK7 with DC50 of 0.2 nM in human primary monocytes (Dmax>95%).

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

NK7-902 is a potent and selective cereblon (CRBN) glue degrader of NEK7 with DC50 of 0.2 nM in human primary monocytes (Dmax>95%).
NK7-902 inhibits the NLRP3 inflammasome in human primary monocytes, selectively blocks both canonical and alternative NLRP3 pathway activation in vitro.
NK7-902 partially inhibits NLRP3-dependent IL-1β release in human PMBCs and whole blood.
NK7-902 degrades NEK7 in mouse cells and in mice.
NK7-902 causes lasting NEK7 degradation in primates, but transient NLRP3 inhibition.

Physicochemical Properties

M.Wt 410.47
Formula C22H26N4O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-(2,6-dioxopiperidin-3-yl)-5-((1S,2R,5S)-2-(ethylamino)-8-azabicyclo[3.2.1]octan-8-yl)isoindoline-1,3-dione

References

1. Sylvain A, et al. Cell Chem Biol. 2025 Jul 7:S2451-9456(25)00200-4.

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