| Cat. No. |
Product Name |
Information |
| PC-23853 |
FF2049
HDAC1-3 PROTAC
|
FF2049 is a first-in-class, selective Fem-1 homologue B (FEM1B)-recruiting HDAC1-3 PROTAC degrader with DC50 value of 257 nM and Dmax of 85% (HDAC1) in MM.1S cells. |
| PC-23842 |
SJ995973
BET PROTAC
|
SJ995973 is a highly potent PROTAC degrader of bromodomain and extra-terminal (BET) proteins with DC50 of 0.87 nM in MV4-11 cells (BRD4) and Dmax=99%, inhibits viability of MV4-11 cells with IC50 of 3 pM. |
| PC-23841 |
SJ44236
BET PROTAC
|
SJ44236 is a highly potent, selective and orally bioavailable BET PROTAC with BRD4 DC50 of 0.127 nM in MV4-11 cells, induces pronounced degradation of BRD2, BRD3 and BRD4. |
| PC-23836 |
Gridegalutamide
AR degrader
|
Gridegalutamide (BMS-986409) is an orally bioavailable androgen receptor (AR) degrader, with potential antineoplastic activity. |
| PC-23795 |
XYD049
GSPT1 degrader
|
XYD049 is a potent, selective CRBN-interacting molecular glue degrader of G1 to S phase transition 1 (GSPT1) with DC50 of 19 nM in 22Rv1 cells. |
| PC-23772 |
HLB-0532259
Aurora-A PROTAC
|
HLB-0532259 is a potent, selective Aurora-A PROTAC degrader, promotes the degradation of Aurora-A, which elicits concomitant N-Myc degradation, with nanomolar potency and excellent selectivity. |
| PC-23771 |
RET PROTAC RD-23
RET PROTAC
|
RET PROTAC RD-23 is a potent, selective and orally bioavailable RET PROTAC degrader with DC50 of 5.6 nM, Dmax =92% in BaF3 cells. |
| PC-23735 |
TEAD PROTAC H122
TEAD PROTAC
|
TEAD PROTAC H122 is a potent, selective TEAD PROTAC degrader with DC50 of 3.0 nM in MSTO-211H cells, shows TEAD1 binding affinity with Ki of 0.3 nM, promotes the degradation of TEAD1, TEAD3, and TEAD4 with similar potency. |
| PC-23715 |
PT-129
G3BP1/2 PROTAC
|
PT-129 is the first potent, selective, and efficacious G3BP1/2 PROTAC degrader, induces degradation of G3BP1 and G3BP2 with DC50 of 5 and 10 μM respectively in L929 cells, Dmax=95%. |
| PC-23702 |
CQ627
RIOK2 degrader
|
CQ627 is the first right open reading frame kinase 2 (RIOK2) molecular glue degrader with DC50 value of 410 nM and Dmax of 83.4% in MOLT4 leukemia cell line via UPS by recruiting E3 ubiquitin ligase RNF126. |
| PC-23675 |
SMD-3040
SMARCA2 PROTAC
|
SMD-3040 is a highly potent, exceptionally selective SMARCA2 PROTAC degrader with DC50 of 12 nM and Dmax = 96% in Hela cells, >500-fold selectivity over SMARC4. |
| PC-23674 |
SMD-3236
SMARCA2 PROTAC
|
SMD-3236 is a highly potent, exceptionally selective SMARCA2 PROTAC degrader with DC50 of 0.5 nM and Dmax = 96% in H838 NSCLC cells, >2000-fold selectivity over SMARC4. |
