| Cat. No. |
Product Name |
Information |
| PC-21003 |
TCIP1
BCL6-BRD4 TCIP
|
BCL6-BRD4 TCIP1 (TCIP1) is a potent BCL6-BRD4 transcriptional/epigenetic chemical inducer of proximity (TCIP) by covalently linking BCL6 binder BI-3812 to BRD4 ligand JQ1, selectively kills DLBCL cells with EC50 of 1.3 nM against KARPAS422 cell. |
| PC-20816 |
PTD10
BTK PROTAC
|
PTD10 is a highly potent BTK PROTAC degrader with DC50 of 0.5 nM in TMD8 cells, inhibits cell growth and induces apoptosis more potently than parent molecule GDC-0853. |
| PC-20755 |
(R)-SL18
ANXA3 degrader
|
(R)-SL18 is a first-in-class, selective Annexin A3 (ANXA3) degrader, induces degradation of ANXA3 in MDA-MB-231 cells with DC50 value of 3.17 uM. |
| PC-20680 |
MRT-2359
GSPT1 PROTAC
|
MRT-2359 (MRT2359) is a potent, selective and orally bioavailable GSPT1-directed molecular glue degrader with DC50 of 5 nM in CAL51 cell line (Dmax=100%). |
| PC-20653 |
DeFer-2
Ferritin PROTAC
|
DeFer-2 is an oleic acid (OA)-based ferritin-targeting PROTAC binding Kd of 17.1 uM, degrades ferritin and rapidly elevates the free iron content, induces pyroptosis. |
| PC-20593 |
CFT1946
mutant BRAF PROTAC
|
CFT1946 (CFT-1946) is a potent, selective CRBN-based PROTAC degrader of mutant BRAF, selectively degrades BRAF V600E (Class I), G469A (Class II), G466V (Class III) mutations and the p61-BRAFV600E splice variant, but not WT BRAF and CRAF. |
| PC-20565 |
CP5V
Cdc20 PROTAC
|
CP5V (apcin-A-PEG5-VHL Ligand 1) is an efficient, selective Cdc20 PROTAC with DC50 of 1.6 uM in both MCF7 and MDA-MB-231 cells, induces mitotic inhibition and suppresses cancer cell proliferation. |
| PC-20349 |
DU-14
PTP1B TC-PTP degrader
|
DU-14 is a highly potent and selective small molecule degrader for both PTP1B and TC-PTP with DC50 values of 4.3 and 4.8 nM, respectively, in HEK293 cells after 16 hours treatment. |
| PC-20323 |
LL-K8-22
CDK8 degarder
|
LL-K8-22 is a potent, selective dual degrader of of CDK8 and cyclin C (MDA-MB-468 cell DC50, 2.52 and 2.64 uM), significantly degrades CDK8 without reducing CDK19 and does not degrade other cyclin proteins. |
| PC-20167 |
TMX-4153
PIP4K2C degrader
|
TMX-4153 (TMX4153) is a bivalent PIP4K2C degrader (MOLT4 cells, DC50=24 nM, Dmax=921% at 1 uM) based on TMX-4084, rapidly and selectively degrades endogenous PIP4K2C. |
| PC-20153 |
TMX-4100
PDE6D degrader
|
TMX-4100 (TMX4100) is a highly potent PDE6D degrader with DC50 of <200 nM in MOLT4 cells, does not degrade CK1α and IKZF1/IKZF3. |
| PC-20152 |
TMX-4113
PDE6D degrader
|
TMX-4113 (TMX4113) is a highly potent PDE6D degrader with DC50 of 40 nM in MM.1S cells, does not degrade CK1α, IKZF1/IKZF3. |
