| Cat. No. |
Product Name |
Information |
| PC-42297 |
ARV-771
BET PROTAC
|
ARV-771 (ARV771) is a potent BET degrader (PROTAC), potently degrades BRD2/3/4 in 22Rv1 cells with DC50< 5 nM. |
| PC-45097 |
ARV-825
BRD4 PROTAC
|
ARV-825 is a hetero-bifunctional PROTAC (Proteolysis Targeting Chimera) that recruits BRD4 to the E3 ubiquitin ligase cereblon, leading to fast, efficient, and prolonged degradation of BRD4 via the proteasome. |
| PC-24279 |
YX0597
CDK9 PROTAC
|
YX0597 is a potent, selective CDK9 PROTAC degrader, potently inhibits GEAC cell growth, especially in radiation-resistant tumor cells. |
| PC-24278 |
TO-1187
HDAC6 PROTAC
|
TO-1187 is a potent, selective, cereblon (CRBN)-based HDAC6 PROTAC degrader with DC50 of 5.81 nM in MM.1S cells (6 h), Dmax of 94%. |
| PC-24265 |
HDAC6 PROTAC 17c
HDAC6 PROTAC
|
HDAC6 PROTAC 17c is a potent, selective CRBN- and VHL-recruiting PROTAC degrader of HDAC6 with DC50 of 14 nM in MM.1S cells, Dmax of 91%, high selective over other HDACs. |
| PC-24242 |
BT-O2C
p300 PROTAC
|
BT-O2C is a potent, selective PROTAC degrader of p300, potently degrades p300 while sparing CBP, is cytotoxic in CIC::DUX4 sarcoma (CDS) cell lines (IC50=152-221 nM). |
| PC-24233 |
PP-C8
CDK12 PROTAC
|
PP-C8 is a potent, selective CDK12-cyclin K complex PROTAC degrader with DC50 of DC50 of 416 nM and 412 nM for CDK12 and CycK protein levels respectively, does not affect CDK13. |
| PC-24182 |
KT-253
MDM2 degrader
|
Seldegamadlin (KT-253, KT253) is a potent, selective heterobifunctional MDM2 degrader (DC50=0.4 nM) and p53 stabilizer. |
| PC-24107 |
ANXA3 degrader 18a5
ANXA3 degrader
|
ANXA3 degrader 18a5 is a highly selective ANXA3 degrader with SPR KD of 0.08 uM, exhibits antiproliferative activity against with IC50 of 0.71 and 1.05 uM, DC50 of 3.12 uM and 1.32 uM in MDA-MB-468 and MDA-MB-231 cells, respectively. |
| PC-24090 |
cGAS PROTAC TH35
cGAS degrader
|
cGAS PROTAC TH35 is an effective, selective CRBN-recruiting cGAS-targeting PROTAC degrader with DC50 of 0.9 uM and 4.6 uM in THP-1 and RAW 264.7 cells respectively, Dmax >90% at 20 uM. |
| PC-24083 |
SK2188
Aurora A PROTAC
|
SK2188 is a potent, highly selective PROTAC degrader of Aurora A with DC50 of 3.9 nM and Dmax of 89% in NGP neuroblastoma cells, induces subsequent reduction of MYCN. |
| PC-24082 |
JB170
Aurora A PROTAC
|
JB170 is a potent, highly selective PROTAC degrader of Aurora A with DC50 of 28 nM and Dmax of 300 nM in MV4-11 cells, linking alisertib to the cereblon-binding molecule Thalidomide. |
