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Chemical Structure : INY-03-041
Catalog No.: PC-72497Not For Human Use, Lab Use Only.
INY-03-041 a pan-AKT degrader (PROTAC) consisting of AKT inhibitor GDC-0068 conjugated to lenalidomide, a recruiter of the E3 ubiquitin ligase substrate adaptor Cereblon (CRBN).
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INY-03-041 a pan-AKT degrader (PROTAC) consisting of AKT inhibitor GDC-0068 conjugated to lenalidomide, a recruiter of the E3 ubiquitin ligase substrate adaptor Cereblon (CRBN).
INY-03-041 exhibits more potent and prolonged effects on downstream signaling than GDC-0068.
INY-03-041 induced potent degradation of all three AKT isoforms in a dose-dependent manner after a 12-hour treatment, with maximal degradation observed between 100 to 250 nM.
| M.Wt | 798.426 | |
| Formula | C44H56ClN7O5 | |
| Appearance | Solid | |
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1. Inchul You, et al. Cell Chem Biol. 2020 Jan 16;27(1):66-73.e7.
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