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Chemical Structure : NJH-2-057
CAS No.: 2858812-70-9
Catalog No.: PC-72837Not For Human Use, Lab Use Only.
NJH-2-057 is a novel CFTR DUBTAC via linking the OTUB1 recruiter EN523 to the CFTR chaperone lumacaftor with C5 alkyl linkers.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $198 | In stock | |
| 10 mg | $298 | In stock | |
| 25 mg | $498 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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NJH-2-057 is a novel CFTR DUBTAC via linking the OTUB1 recruiter EN523 to the CFTR chaperone lumacaftor with C5 alkyl linkers.
NJH-2-057 robustly stabilizes ΔF508-CFTR protein levels, leading to improved chloride channel conductance in human cystic fibrosis bronchial epithelial cells.
Deubiquitinase-targeting chimeras (DUBTACs), heterobifunctional small molecules consisting of a deubiquitinase recruiter linked to a protein-targeting ligand, to stabilize the levels of specific proteins degraded in a ubiquitin-dependent manner.
| M.Wt | 810.856 | |
| Formula | C43H44F2N6O8 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-(5-(3-(5-(4-acryloyl-2-oxopiperazin-1-yl)furan-2-yl)propanamido)pentyl)-3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropane-1-carboxamido)-3-methylpyridin-2-yl)benzamide |
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1. Henning NJ, et al. Nat Chem Biol. 2022 Feb 24. doi: 10.1038/s41589-022-00971-2.
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