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Chemical Structure : MS910
Catalog No.: PC-72325Not For Human Use, Lab Use Only.
MS910 (MS-910) is the first CRBN-recruiting MEK1/2 degrader (PROTC) with HT29 DC50 of 118/55 nM for MEK1/2 degradation, respectively.
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MS910 (MS-910) is the first CRBN-recruiting MEK1/2 degrader (PROTC) with HT29 DC50 of 118/55 nM for MEK1/2 degradation, respectively.
MS910 displays antiproliferation potency against HT29 cell with GI50 of 330 nM, degrade MEK1 and MEK2 and inhibit pERK signaling in a time-dependent manner.
| M.Wt | 984.766 | |
| Formula | C41H48F3IN6O11 | |
| Appearance | Solid | |
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1. Jianping Hu, et al. J Med Chem. 2020 Dec 24;63(24):15883-15905.
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