MS910 | MEK1/2 degrader | Probechem Biochemicals

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Chemical Structure : MS910

MS910 (MS-910)

Catalog No.: PC-72325Not For Human Use, Lab Use Only.

MS910 (MS-910) is the first CRBN-recruiting MEK1/2 degrader (PROTC) with HT29 DC50 of 118/55 nM for MEK1/2 degradation, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

MS910 (MS-910) is the first CRBN-recruiting MEK1/2 degrader (PROTC) with HT29 DC50 of 118/55 nM for MEK1/2 degradation, respectively.
MS910 displays antiproliferation potency against HT29 cell with GI50 of 330 nM, degrade MEK1 and MEK2 and inhibit pERK signaling in a time-dependent manner.

Physicochemical Properties

M.Wt	984.766
Formula	C41H48F3IN6O11
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-((1-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)amino)-3,6,9,12,15-pentaoxa-18-azahenicosan-21-yl)oxy)-3,4-di-fluoro-2-((2-fluoro-4-iodophenyl)amino)benzamide

References

1. Jianping Hu, et al. J Med Chem. 2020 Dec 24;63(24):15883-15905.

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MS910 (MS-910)

Biological Activity

Physicochemical Properties

References

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