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Chemical Structure : GNE-987
CAS No.: 2417371-71-0
Catalog No.: PC-72911Not For Human Use, Lab Use Only.
GNE-987 (GNE987) is a highly potent chimeric BET degrader, exhibits BRD4 degradation activity in EOL-1 AML cell line with DC50 of 30 pM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 1 mg | $398 | In stock | |
| 2 mg | $548 | In stock | |
| 5 mg | Get quote | ||
| 10 mg | Get quote | ||
| 25 mg | Get quote |
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GNE-987 (GNE987) is a highly potent chimeric BET degrader, exhibits BRD4 degradation activity in EOL-1 AML cell line with DC50 of 30 pM.
| M.Wt | 1096.32 | |
| Formula | C56H67F2N9O8S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
7-(3,5-difluoropyridin-2-yl)-N-(11-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-11-oxoundecyl)-2-methyl-10-((methylsulfonyl)methyl)-3-oxo-3,4,6,7-tetrahydro-2H-2,4,7-triazadibenzo[cd,f]azulene-9-carboxamide |
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1. Thomas H Pillow, et al. ChemMedChem. 2020 Jan 7;15(1):17-25.
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