| Cat. No. |
Product Name |
Information |
| PC-23399 |
WEE1-CK1α molecular glue degrader 1
WEE1/CK1α degrader
|
WEE1-CK1α molecular glue degrader 1 is a CRBN-dependent WEE1 molecular glue degrader that degrade WEE1 and CK1α with DC50 of 1.1 nM and 3.4 nM in MOLT-4 cells respectively. |
| PC-23385 |
MD-265
MDM2 PROTAC
|
MD-265 is a potent PROTAC MDM2 degrader, potently inhibits RS4;11 cell line with IC50 of 0.7 nM, induces strong p53 activation in cancer cells carrying wild-type p53. |
| PC-23329 |
BRD9 PROTAC C6
BRD9 PROTAC
|
BRD9 PROTAC C6 is a potent, selective and orally active BRD9 PROTAC degrader with DC50 of 1.02 nM in MV4-11 cells (24 h), without effect on BRD4 or BRD7. |
| PC-23302 |
SIAIS562055
SOS1 PROTAC
|
SIAIS562055 is a potent, selective SOS1 PROTAC degrader (KD=95.9 nM) which is designed by connecting a CRBN ligand to an analogue of the SOS1 inhibitor BI-3406, selectively degrades SOS1 with DC50 values of 62.5 nM and 8.4 nM in K562 and KU812 cells. |
| PC-23265 |
LDD 39
RET degrader
|
LDD 39 is a pyrazolopyridine-based heterobifunctional RET ligand-directed degrader with IC50 of 2.0/1.1/7.5 nM for WT RET/V804M/G810R respectively, and DC50 of 0.97/3.2/6.4 nM in TPC-1 cells against both RET WT and the two mutants. |
| PC-23239 |
SZU-B6
SIRT6 PROTAC
|
SZU-B6 is a highly potent and selective SIRT6 PROTAC degrader with DC50 of 45.29 nM and 154.28 nM in SK-HEP-1 and Huh-7 cells respectively. |
| PC-23208 |
CFT-1297
BRD4 PROTAC
|
CFT-1297 is a potent, selective BRD4 PROTAC degrader with DC50 of 5 nM and Dmax of 97% in HEK293T cells, targets the BD1 domain of BRD4. |
| PC-23148 |
YJ9069
CDK12/13 PROTAC
|
YJ9069 is a selective CDK12/13 PROTAC degrader, exhibits preferential cytotoxicity in multiple cancers. |
| PC-23129 |
SIAIS361034
Bcl-xL PROTAC
|
SIAIS361034 is a potent, selective PROTAC degrader of Bcl-xL, selectively degrades Bcl-xL and significantly inhibits the Hh pathway activity SIAIS361034 with IC50 of 120 nM. |
| PC-23104 |
METTL3 PROTAC KH12
METTL3 PROTAC
|
KH12 is a potent METTL3 PROTAC degrader with DC50 of 220 nM in MOLM-13 cells. |
| PC-23062 |
MG-277
GSPT1 degrader
|
MG-277 is a potent molecular glue GSPT1 degrader, effectively degrades GSPT1 protein in a dose- and time-dependent manner in RS4;11 cell line with DC50 of 1.3 nM. |
| PC-23037 |
PROTAC AGB1
BromoTagged proteins PROTAC
|
PROTAC AGB1 is a potent, fast, and selective degrader of BromoTagged proteins with DC50 of <15 nM. |
