| Cat. No. |
Product Name |
Information |
| PC-27120 |
SMD-6346
SMARCA2 PROTAC
|
SMD-6346 is a highly potent, selective and orally available SMARCA2 PROTAC degrader with DC50 of 3.3 nM and Dmax > 90%, shows much weaker activity against SMARCA4 (DC50 > 1000 nM, Dmax = 46%). |
| PC-27096 |
HDAC6 PROTAC 15
HDAC6 PROTAC
|
HDAC6 PROTAC 15 is a potent, selective HDAC6 degrader with pDC50 of 9.1 in bronchial epithelium cells, reduces α-tubulin hyperacetylation without affecting histone-3 acetylation. |
| PC-27030 |
dCBP-30
CBP/p300 degrader
|
dCBP-30 is a potent, selective and orally active dual CBP/p300 degrader with DC50 at 4 h of 0.05 nM (CBP) and 0.04 nM (p300). |
| PC-26976 |
R4VPL3-1
RNF4 degrader
|
R4VPL3-1 is a PROTAC-like molecule that induces proteasomal degradation of RNF4, also induces the elimination of VHL in cancer cells. |
| PC-26975 |
RNF4 PROTAC RD12
RNF4 degrader
|
RNF4 PROTAC RD12 is a first-in-class, selective Ring Finger Protein 4 (RNF4) PROTAC degrader, selectively degrades RNF4 through UPS and induces DNA damage. |
| PC-26928 |
XYD224
BRD9 degrader
|
XYD224 is a highly potent and selective BRD9 degrader with DC50 of 7.3 nM in MV4-11 cells, inhibits cell proliferation of a panel of AML cell lines with IC50 of 33 nM in MV4-11 cells. |
| PC-26926 |
M9101
Aurora A PROTAC
|
M9101 is a potent, selective and in vivo active Aurora A PROTAC degrader with DC50 value of 2.3 nM in MD-MBA-231 cells. |
| PC-26875 |
KTX-545
IRAK4 degrader
|
KTX-545 (KTX545) is a potent, selective IRAK4-targeting degrader with DC50 of 0.9 nM determined in in vitro assays with human monocytes. |
| PC-26832 |
dCDK9-010
P-TEFb degrader
|
dCDK9-010 is a highly efficient and selective positive transcription elongation factor b (P-TEFb) complex PROTAC degrader with DC50 of 0.5 uM in NCI-H226 cells, recruits the MDM2 E3 ligase to induce proteasome-dependent degradation of CDK9 and all cyclin T isoforms. |
| PC-26772 |
MRT-5702
G3BP2 molecular glue degrader
|
MRT-5702 is a specific molecular glue degrader of G3BP2 targeting cereblon (CRBN), forms a CRBN-MRT-5702D-G3BP2 ternary complex to activate the ubiquitin-proteasome system for G3BP2 degradation. |
| PC-26727 |
p300 degrader 27
p300 PROTAC degrader
|
p300 degrader 27 is a potent, paralog-selective p300 protein degrader with DC50 of 22.5 nM in U2OS cells, does not affect CBP. |
| PC-26648 |
LD5095
RIPK1 PROTAC
|
LD5095 is a potent, selective cereblon (CRBN)-recruiting RIPK1 degrader with DC50 of 1.4, 1.2, and 2.3 nM and Dmax>90% for endogenous RIPK1 in WT Jurkat, MOLM14, and U937 cell lines. |
