Chemical Structure : KT-333
CAS No.:
2502186-79-8
KT-333
(KT333)
Catalog No.: PC-24047Not For Human Use, Lab Use Only.
KT-333 (KT333) is a potent, highly specific potent heterobifunctional PROTAC degrader of STAT3 with DC50 of 2.5 -11.8 nM in anaplastic T cell lymphoma (ALCL) lines.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
KT-333 (KT333) is a potent, highly specific potent heterobifunctional PROTAC degrader of STAT3 with DC50 of 2.5 -11.8 nM in anaplastic T cell lymphoma (ALCL) lines.
KT-333 exhibits selective degradation of STAT3 over nearly 9000 proteins, including other STAT family members.
KT-333 treatment led to rapid apoptosis in tumor cells expressing NPM-ALK fusion oncoproteins.
KT-333 induces a significant reduction in STAT3 and MCL1 protein levels within two weeks of treatment in a cell derived xenograft model of Ven-res AML.
Physicochemical Properties
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M.Wt
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1257.79
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Formula
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C60H74ClN10O14PS
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(2-(((5S,8S,10aR)-3-Acetyl-8-(((S)-5-amino-1-(2-chloro-3-(4-(((S)-1-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-4-oxobutyl)phenoxy)-5-oxopentan-2-yl)carbamoyl)-6-oxodecahydropyrrolo[1,2-a][1,5]diazocin-5-yl)carbamoyl)-1H-indole-5-carbonyl)phosphonic acid
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References
1. Chakraborty S, et al. bioRxiv [Preprint]. 2024 Aug 7:2024.08.05.599788.
2. Phillip CC Liu, et al. Blood (2021) 138 (Supplement 1): 1865.
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