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RDN8011

Chemical Structure : RDN8011

CAS No.:

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RDN8011 (RDN-8011)

Catalog No.: PC-24058Not For Human Use, Lab Use Only.

RDN8011 is a potent, selective first-in-class PROTAC degrader of KDM4 with DC50 of 37-50 nM for KDM4A/KDM4B/KDM4C in in KYSE-150 cells, while sparing KDM4D.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    RDN8011 is a potent, selective first-in-class PROTAC degrader of KDM4 with DC50 of 37-50 nM for KDM4A/KDM4B/KDM4C in in KYSE-150 cells, while sparing KDM4D.
    RDN8011 acts KDM4A degradation mediated by the ubiquitin-proteasome system (UPS).
    RDN8011 (0-10 uM) upregulates H3K36 methylation and induces cell cycle arrest and apoptosis in KYSE-150 cells.

    Physicochemical Properties

    M.Wt 1002.29
    Formula C56H71N7O8S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    3-((((R)-7-((4-((10-(((S)-1-((2S,4R)-4-Hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-10-oxodecyl)oxy)phenyl)(methyl)amino)chroman-4-yl)methyl)amino)isonicotinic acid

    References

    1. Rao D, et al. Eur J Med Chem. 2025 Feb 19;288:117410.

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