RDN8011

Chemical Structure : RDN8011

Catalog No.: PC-24058Not For Human Use, Lab Use Only.

RDN8011 is a potent, selective first-in-class PROTAC degrader of KDM4 with DC50 of 37-50 nM for KDM4A/KDM4B/KDM4C in in KYSE-150 cells, while sparing KDM4D.

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Biological Activity

RDN8011 is a potent, selective first-in-class PROTAC degrader of KDM4 with DC50 of 37-50 nM for KDM4A/KDM4B/KDM4C in in KYSE-150 cells, while sparing KDM4D.
RDN8011 acts KDM4A degradation mediated by the ubiquitin-proteasome system (UPS).
RDN8011 (0-10 uM) upregulates H3K36 methylation and induces cell cycle arrest and apoptosis in KYSE-150 cells.

Physicochemical Properties

M.Wt	1002.29
Formula	C56H71N7O8S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES

References

1. Rao D, et al. Eur J Med Chem. 2025 Feb 19;288:117410.

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RDN8011

Biological Activity

Physicochemical Properties

References

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