| Cat. No. |
Product Name |
Information |
| PC-49078 |
YM281
EZH2 PROTAC
|
YM281 is potent, EPZ6438-based, von Hippel-Lindau (VHL)-recruiting PROTAC degrader of EZH2, induces robust cell viability inhibition in DLBCL and other subtypes of lymphomas, displays promising antitumor activities in lymphoma xenografts and patient-derived primary lymphoma cells. |
| PC-49077 |
MS8815
EZH2 PROTAC
|
MS8815 is a potent, selective EZH2 PROTAC degrader with IC50 of 8.6 nM against EZH2, induces robust EZH2 degradation in a concentration-, time-, and proteasome-dependent manner in TNBC cells. |
| PC-49061 |
WDR5 PROTAC MS40
WDR5 PROTAC
|
WDR5 PROTAC MS40 is a cereblon (CRBN)-recruiting proteolysis targeting chimera (PROTAC) of WDR5, selectively degrades WDR5 and the Ikaros zinc finger (IKZF) transcription factors IKZF1 and IKZF3. |
| PC-49057 |
CDK2 degrader CPS2
CDK2 PROTAC
|
CDK2 degrader CPS2 is a potent, selective CDK2 degarder (PROTAC) with IC50 of 24 nM, potently and specifically induces CDK2 degradation in various cancer cell lines (MDA-MB-231, DC50=8 nM; MV-4-11, DC50=1 nM). |
| PC-49045 |
MD-224
MDM2 PROTAC
|
MD-224 is a small-molecule MDM2 degrader based on the proteolysis targeting chimera (PROTAC), effectively induces rapid degradation of MDM2 at concentrations <1 nM in human leukemia cells. |
| PC-49044 |
ARD-69
AR PROTAC
|
ARD-69 is a highly potent PROTAC degrader of androgen receptor (AR), effectively induces degradation of AR protein in AR-positive prostate cancer cell lines LNCaP, VCaP, and 22Rv1 with DC50 values of 0.86, 0.76, and 10.4 nM, respectively. |
| PC-47084 |
JCS-1
DcpS PROTAC
|
JCS-1 is a RG3039-based degarder (PROTAC) of the RNA decapping scavenger protein DcpS exhibiting effective degradation of DcpS at nanomolar concentrations, non-covalently binds DcpS and recruits the E3 ligase VHL, induces potent, rapid, and sustained DcpS degradation in AML cell lines. |
| PC-47018 |
ZXH-1-161
GSPT1 PROTAC
|
ZXH-1-161 is a potent, selective small-molecule GSPT1 degrader, inhibits ceell viability in MM1.S with IC50 of 39 nM. |
| PC-47017 |
SJ6986
GSPT1/2 PROTAC
|
SJ6986 is a potent, selective, and orally bioavailable small-molecule GSPT1/2 degrader with DC50 of 2.1 nM (GSPT1), demonstrates antiproliferative activities in leukemia cell lines MV4-11 and MHH-CALL-4 with EC50 of 1.5 and 0.4 nM, respectively. |
| PC-38903 |
U7D-1
USP7 PROTAC
|
U7D-1 is a selective USP7-degrading Proteolysis Targeting Chimera (PROTAC) with DC50 of 33 nM in RS4;11 cells. |
| PC-38738 |
Degradomer D-1
IRAK3 PROTAC
|
Degradomer D-1 is a selective proteasomal degrader of IRAK3 with Kd of 100 nM, DC50 of 94 nM, displays no binding affinity against IRAK4 (Ki >10 uM). |
| PC-38718 |
CRBN(BRAF)-24
BRAF V600E PROTAC
|
CRBN(BRAF)-24 is a potent small molecule degrader against oncogenic BRAF V600E protein, potently degrades BRAFV600E in a ubiquitin–proteasome system (UPS)-dependent manner and inhibits the proliferation of BRAFV600E-driven cancer cells. |
