| Cat. No. |
Product Name |
Information |
| PC-49454 |
A947
SMARCA2 PROTAC
|
A-947 (A947) is a potent and selective PROTAC targeting SMARCA2, potently degrades SMARCA2 in SW1573 cells with DC50 value of 39 pM, maximal degradation of 96% at 10 nM. |
| PC-49439 |
CRBN(FLT3)-8
FLT3-ITD degarder
|
CRBN(FLT3)-8 a highly potent FLT3 degrader by introducing gilteritinib into targeted protein degradation technology, potently degrades FLT3-ITD via UPS and inhibits the proliferation of FLT3-ITD mutant AML cells more effectively than gilteritinib. |
| PC-49392 |
UBX-382
BTK PROTAC
|
UBX-382 (UBX382) is a potent and orally available proteolysis-targeting chimera (PROTAC) that induces potent BTK degradation in DLBCL cell line with DC50 of 4.5 nM. |
| PC-49380 |
INY-06-061
ERK5 PROTAC
|
INY-06-061 is a potent and selective heterobifunctional degrader of ERK5 with binding Kd of 12 nM and DC50 of 21 nM in MOLT4 cells (5h treatment). |
| PC-49367 |
dBRD4-BD1
BRD4 PROTAC
|
dBRD4-BD1 is a potent, selective degrader of BRD4 with DC50 of 280 nM, Dmax 77%. |
| PC-49352 |
AZ6421
ER PROTAC
|
AZ'6421 is a Protcolysis Targeting Chimera (PROTAC) to selectively degrade estrogen receptor, shows ER binding and ER degradation with IC50 and DC50 values of 0.6 nM and 0.4 nM, respectively in MCF-7 cell lines. |
| PC-49328 |
HPP-9
BET PROTAC
|
HPP-9 is a potent BET bromodomain degrader that acts through a PROTAC mechanism, HPP-9 is a long-acting Hedgehog pathway inhibitor. |
| PC-49310 |
SJPYT-195
GSPT1 PROTAC
|
SJPYT-195 is a small molecule glue degrader (PROTAC) of the translation termination factor GSPT1, consists of SPA70 derivative to ligandof the E3 substrate receptor cereblon (CRBN), causes subsequent reduction of PXR protein. |
| PC-49282 |
XL01126
LRRK PROTAC
|
XL01126 (XL 01126) is a fast and potent degrader of LRRK2 in multiple cell lines with DC50 values of 15-72 nM, Dmax values ranging from 82 to 90%, and degradation half-lives spanning from 0.6 to 2.4 h. |
| PC-49208 |
MS159
NSD2 PROTAC
|
MS159 is a first-in-class NSD2 proteolysis targeting chimera (PROTAC) degrader of nuclear receptor binding SET domain protein 2 (NSD2), also effectively degrads CRBN neo-substrates IKZF1 and IKZF3, but not GSPT1. |
| PC-49151 |
QA-68-ZU81
BRD9 PROTAC
|
QA-68-ZU81 (QA-68) is a EA-89-based BRD9 degrader that incorporates the EA-89 warhead into a cereblon (CRBN)-targeting proteolysis-targeting chimera (PROTAC). |
| PC-49144 |
SJ1008030
JAK2 PROTAC
|
SJ1008030 is a potent, specific JAK2-degrading, GSPT1-sparing PROTAC, potently inhibits MHH-CALL-4 cell growth with IC50 of 5.4 nM. |
