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Chemical Structure : SKLB-0124
Catalog No.: PC-22381Not For Human Use, Lab Use Only.
SKLB-0124 is a selective, first-in-class degrader for the protein arginine methyltransferase 6 (PRMT6) with EC50 of 15.4 uM for HCC827 cells.
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SKLB-0124 is a selective, first-in-class degrader for the protein arginine methyltransferase 6 (PRMT6) with EC50 of 15.4 uM for HCC827 cells.
SKLB-0124 shows significantly reduced inhibitory activity against HCC827 cells and MDA-MB-435 cells with IC50 of 5.9 and 5.1 uM, respectively.
SKLB-0124 is a selective methyltransferase degrader for PRMT6, but not for PRMT1 and PRMT8.
SKLB-0124 induced cell cycle arrest and apoptosis in HCC827 cells and MDA-MB-435 cells.
| M.Wt | 531.75 | |
| Formula | C32H45N5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Hongling Yang, et al. Bioorg Chem. 2024 May 10:148:107439.
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