Catalog No.: PC-22535Not For Human Use, Lab Use Only.
KI-CDK9d-32 is a highly potent and selective CDK9 degrader with DC50 of 0.89 nM in MOLT-4 cells (4h) and Dmax of 97.7%, induces rapid reduction of MYC protein levels.
KI-CDK9d-32 is a highly potent and selective CDK9 degrader with DC50 of 0.89 nM in MOLT-4 cells (4h) and Dmax of 97.7%, induces rapid reduction of MYC protein levels.
KI-CDK9d-32 significantly suppresses transcription of MYC in both a dose- and time dependent manner.
KI-CDK9d-32 represses canonical MYC pathways and leads to a destabilization of nucleolar homeostasis.
KI-CDK9d-32 has strong cytotoxic effects relative to the inhibitors used, but activity is limited in cells with high ABCB1 level.
