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Chemical Structure : KI-CDK9d-32
Catalog No.: PC-22535Not For Human Use, Lab Use Only.
KI-CDK9d-32 is a highly potent and selective CDK9 degrader with DC50 of 0.89 nM in MOLT-4 cells (4h) and Dmax of 97.7%, induces rapid reduction of MYC protein levels.
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KI-CDK9d-32 is a highly potent and selective CDK9 degrader with DC50 of 0.89 nM in MOLT-4 cells (4h) and Dmax of 97.7%, induces rapid reduction of MYC protein levels.
KI-CDK9d-32 significantly suppresses transcription of MYC in both a dose- and time dependent manner.
KI-CDK9d-32 represses canonical MYC pathways and leads to a destabilization of nucleolar homeostasis.
KI-CDK9d-32 has strong cytotoxic effects relative to the inhibitors used, but activity is limited in cells with high ABCB1 level.
| M.Wt | 703.85 | |
| Formula | C39H45N9O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Mohammed A Toure, et al. bioRxiv. 2024 May 15:2024.05.14.593352.
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