Chemical Structure : KI-CDK9d-32
CAS No.:
KI-CDK9d-32
(CDK9 PROTAC)
Catalog No.: PC-22535Not For Human Use, Lab Use Only.
KI-CDK9d-32 is a highly potent and selective CDK9 degrader with DC50 of 0.89 nM in MOLT-4 cells (4h) and Dmax of 97.7%, induces rapid reduction of MYC protein levels.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
KI-CDK9d-32 is a highly potent and selective CDK9 degrader with DC50 of 0.89 nM in MOLT-4 cells (4h) and Dmax of 97.7%, induces rapid reduction of MYC protein levels.
KI-CDK9d-32 significantly suppresses transcription of MYC in both a dose- and time dependent manner.
KI-CDK9d-32 represses canonical MYC pathways and leads to a destabilization of nucleolar homeostasis.
KI-CDK9d-32 has strong cytotoxic effects relative to the inhibitors used, but activity is limited in cells with high ABCB1 level.
Physicochemical Properties
|
M.Wt
|
703.85
|
|
Formula
|
C39H45N9O4
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
4-((4-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)piperazin-1-yl)methyl)-N-((1R,3R)-3-((5-propylpyrazolo[1,5-a]pyrimidin-7-yl)amino)cyclopentyl)benzamide
|
References
1. Mohammed A Toure, et al. bioRxiv. 2024 May 15:2024.05.14.593352.
Contact Us
sales@probechem.com
