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Chemical Structure : MS140
CAS No.: 2229974-83-6
Catalog No.: PC-22394Not For Human Use, Lab Use Only.
MS140 is a potent and selective, CRBN-dependent CDK4/6-degrader (PROTAC) with IC50 of 0.38 nM and 0.28 nM against CDK4/cyclin D1 and CDK6/cyclin D1, suppresses Rb/E2F signaling and reduces CDK4 and CDK6 protein levels.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $138 | In stock | |
| 25 mg | $258 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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MS140 is a potent and selective, CRBN-dependent CDK4/6-degrader (PROTAC) with IC50 of 0.38 nM and 0.28 nM against CDK4/cyclin D1 and CDK6/cyclin D1, suppresses Rb/E2F signaling and reduces CDK4 and CDK6 protein levels.
MS140 does not degrade CDK7 or CDK9.
MS140 is more effective than CDK4/6 inhibitors in CDK4/6i-S tumor cells.
| M.Wt | 760.81 | |
| Formula | C39H40N10O7 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-[[2-[4-[6-[(6-Acetyl-8-cyclopentyl-7,8-dihydro-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2-yl)amino]-3-pyridinyl]-1-piperazinyl]-2-oxoethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione |
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1. Xuewei Wu, et al. Nat Cancer. 2021 Apr;2(4):429-443.
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