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Chemical Structure : XZ9002
Catalog No.: PC-22578Not For Human Use, Lab Use Only.
XZ9002 is a first-in-class HDAC3-specific PROTAC that potently degrades HDAC3 with DC50 of 42 nM in MDA-MB-468 cells.
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XZ9002 is a first-in-class HDAC3-specific PROTAC that potently degrades HDAC3 with DC50 of 42 nM in MDA-MB-468 cells.
XZ9002 shows no effect on the protein levels of HDACs 1, 2, and 6.
Proteasome inhibitor MG132 blocks XZ9002-induced HDAC3 degradation.
XZ9002 has potent antiproliferative activity against cancer cells.
| M.Wt | 852.11 | |
| Formula | C47H61N7O6S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Yufeng Xiao, et al. Chem Commun (Camb). 2020 Aug 25;56(68):9866-9869.
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