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XZ9002

Chemical Structure : XZ9002

CAS No.: 2596365-98-7

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XZ9002 (XZ-9002)

Catalog No.: PC-22578Not For Human Use, Lab Use Only.

XZ9002 is a first-in-class HDAC3-specific PROTAC that potently degrades HDAC3 with DC50 of 42 nM in MDA-MB-468 cells.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

XZ9002 is a first-in-class HDAC3-specific PROTAC that potently degrades HDAC3 with DC50 of 42 nM in MDA-MB-468 cells.
XZ9002 shows no effect on the protein levels of HDACs 1, 2, and 6.
Proteasome inhibitor MG132 blocks XZ9002-induced HDAC3 degradation.
XZ9002 has potent antiproliferative activity against cancer cells.

Physicochemical Properties

M.Wt 852.11
Formula C47H61N7O6S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N1-((S)-1-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)-N8-(4'-(2-propylhydrazine-1-carbonyl)-[1,1'-biphenyl]-4-yl)octanediamide

References

1. Yufeng Xiao, et al. Chem Commun (Camb). 2020 Aug 25;56(68):9866-9869.

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