Catalog No.: PC-22586Not For Human Use, Lab Use Only.
dWIZ-2 is a small molecular glue degrader of the WIZ transcription factor and CRBN-based small-molecule inducer of fetal hemoglobin (HbF) in erythroblasts.
dWIZ-2 is a small molecular glue degrader of the WIZ transcription factor and CRBN-based small-molecule inducer of fetal hemoglobin (HbF) in erythroblasts.
dWIZ-2 increases CRBN-WIZ association.
dWIZ-2 induces HbF expression by direct binding to CRBN and subsequent recruitment and proteasomal degradation of WIZ through WIZ(ZF7).
dWIZ-2 potently degraded WIZ in primary human erythroblasts in vitro.
dWIZ-2 (10 uM) increases both the percentage of HbF-expressing cells as well as total HbF in SCD-derived erythroblasts.
dWIZ-2 (30-100 mg/kg) is well tolerated and induced HbF in humanized mice and cynomolgus monkeys.
