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Chemical Structure : dWIZ-2
CAS No.: 2654011-51-3
Catalog No.: PC-22586Not For Human Use, Lab Use Only.
dWIZ-2 is a small molecular glue degrader of the WIZ transcription factor and CRBN-based small-molecule inducer of fetal hemoglobin (HbF) in erythroblasts.
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dWIZ-2 is a small molecular glue degrader of the WIZ transcription factor and CRBN-based small-molecule inducer of fetal hemoglobin (HbF) in erythroblasts.
dWIZ-2 increases CRBN-WIZ association.
dWIZ-2 induces HbF expression by direct binding to CRBN and subsequent recruitment and proteasomal degradation of WIZ through WIZ(ZF7).
dWIZ-2 potently degraded WIZ in primary human erythroblasts in vitro.
dWIZ-2 (10 uM) increases both the percentage of HbF-expressing cells as well as total HbF in SCD-derived erythroblasts.
dWIZ-2 (30-100 mg/kg) is well tolerated and induced HbF in humanized mice and cynomolgus monkeys.
| M.Wt | 385.46 | |
| Formula | C21H27N3O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
3-(5-(((R)-1-ethylpiperidin-2-yl)methoxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione |
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1. PAMELA Y. TING, et al. SCIENCE, VOL. 385, NO. 670404 JUL 2024 : 91-99
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